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Interplay between Extracellular Matrix and Neutrophils in Diseases
The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302397/ https://www.ncbi.nlm.nih.gov/pubmed/34327245 http://dx.doi.org/10.1155/2021/8243378 |
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author | Zhu, Yanyan Huang, Yumeng Ji, Qian Fu, Shengqiao Gu, Jia Tai, Ningzheng Wang, Xu |
author_facet | Zhu, Yanyan Huang, Yumeng Ji, Qian Fu, Shengqiao Gu, Jia Tai, Ningzheng Wang, Xu |
author_sort | Zhu, Yanyan |
collection | PubMed |
description | The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophils are the most abundant immune cells in circulation and play key roles in orchestrating a complex series of events during inflammation. Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. In turn, ECM can remodel the inflammatory microenvironment by regulating the function of neutrophils, which drives disease progression. Both the presence of ECM and the interplay between neutrophils and their extracellular matrices are considered an important and outstanding mechanistic aspect of inflammation. In this review, the importance of ECM will be considered, together with the discussion of recent advances in understanding the underlying mechanisms of the intricate interplay between ECM and neutrophils. A better comprehension of immune cell-matrix reciprocal dependence has exciting implications for the development of new therapeutic options for neutrophil-associated infectious and inflammatory diseases. |
format | Online Article Text |
id | pubmed-8302397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83023972021-07-28 Interplay between Extracellular Matrix and Neutrophils in Diseases Zhu, Yanyan Huang, Yumeng Ji, Qian Fu, Shengqiao Gu, Jia Tai, Ningzheng Wang, Xu J Immunol Res Review Article The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differentiation, proliferation, and migration. Neutrophils are the most abundant immune cells in circulation and play key roles in orchestrating a complex series of events during inflammation. Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. In turn, ECM can remodel the inflammatory microenvironment by regulating the function of neutrophils, which drives disease progression. Both the presence of ECM and the interplay between neutrophils and their extracellular matrices are considered an important and outstanding mechanistic aspect of inflammation. In this review, the importance of ECM will be considered, together with the discussion of recent advances in understanding the underlying mechanisms of the intricate interplay between ECM and neutrophils. A better comprehension of immune cell-matrix reciprocal dependence has exciting implications for the development of new therapeutic options for neutrophil-associated infectious and inflammatory diseases. Hindawi 2021-07-16 /pmc/articles/PMC8302397/ /pubmed/34327245 http://dx.doi.org/10.1155/2021/8243378 Text en Copyright © 2021 Yanyan Zhu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Yanyan Huang, Yumeng Ji, Qian Fu, Shengqiao Gu, Jia Tai, Ningzheng Wang, Xu Interplay between Extracellular Matrix and Neutrophils in Diseases |
title | Interplay between Extracellular Matrix and Neutrophils in Diseases |
title_full | Interplay between Extracellular Matrix and Neutrophils in Diseases |
title_fullStr | Interplay between Extracellular Matrix and Neutrophils in Diseases |
title_full_unstemmed | Interplay between Extracellular Matrix and Neutrophils in Diseases |
title_short | Interplay between Extracellular Matrix and Neutrophils in Diseases |
title_sort | interplay between extracellular matrix and neutrophils in diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302397/ https://www.ncbi.nlm.nih.gov/pubmed/34327245 http://dx.doi.org/10.1155/2021/8243378 |
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