Cargando…
Signal strength controls the rate of polarization within CTLs during killing
Cytotoxic T lymphocytes (CTLs) are key effector cells in the immune response against viruses and cancers, killing targets with high precision. Target cell recognition by CTL triggers rapid polarization of intracellular organelles toward the synapse formed with the target cell, delivering cytolytic g...
Autores principales: | Frazer, Gordon L., Gawden-Bone, Christian M., Dieckmann, Nele M.G., Asano, Yukako, Griffiths, Gillian M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302442/ https://www.ncbi.nlm.nih.gov/pubmed/34292303 http://dx.doi.org/10.1083/jcb.202104093 |
Ejemplares similares
-
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
por: Gawden-Bone, Christian M., et al.
Publicado: (2019) -
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes
por: Gawden-Bone, Christian M., et al.
Publicado: (2018) -
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
por: Randzavola, Lyra O., et al.
Publicado: (2019) -
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse
por: Lee, Jeansun, et al.
Publicado: (2018) -
Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver
por: Liu, Lei, et al.
Publicado: (2021)