Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks

Opn7b is a non-visual G protein-coupled receptor expressed in zebrafish. Here we find that Opn7b expressed in HEK cells constitutively activates the G(i/o) pathway and illumination with blue/green light inactivates G protein-coupled inwardly rectifying potassium channels. This suggests that light ac...

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Detalles Bibliográficos
Autores principales: Karapinar, Raziye, Schwitalla, Jan Claudius, Eickelbeck, Dennis, Pakusch, Johanna, Mücher, Brix, Grömmke, Michelle, Surdin, Tatjana, Knöpfel, Thomas, Mark, Melanie D., Siveke, Ida, Herlitze, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302595/
https://www.ncbi.nlm.nih.gov/pubmed/34301944
http://dx.doi.org/10.1038/s41467-021-24718-0

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