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KRAP tethers IP(3) receptors to actin and licenses them to evoke cytosolic Ca(2+) signals

Regulation of IP(3) receptors (IP(3)Rs) by IP(3) and Ca(2+) allows regenerative Ca(2+) signals, the smallest being Ca(2+) puffs, which arise from coordinated openings of a few clustered IP(3)Rs. Cells express thousands of mostly mobile IP(3)Rs, yet Ca(2+) puffs occur at a few immobile IP(3)R cluster...

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Detalles Bibliográficos
Autores principales:	Thillaiappan, Nagendra Babu, Smith, Holly A., Atakpa-Adaji, Peace, Taylor, Colin W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302619/ https://www.ncbi.nlm.nih.gov/pubmed/34301929 http://dx.doi.org/10.1038/s41467-021-24739-9

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