The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vi...

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Detalles Bibliográficos
Autores principales: Ning, Li, Rui, Xiong, Bo, Wang, Qing, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302660/
https://www.ncbi.nlm.nih.gov/pubmed/34301918
http://dx.doi.org/10.1038/s41419-021-04019-6
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author Ning, Li
Rui, Xiong
Bo, Wang
Qing, Geng
author_facet Ning, Li
Rui, Xiong
Bo, Wang
Qing, Geng
author_sort Ning, Li
collection PubMed
description Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.
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spelling pubmed-83026602021-08-12 The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury Ning, Li Rui, Xiong Bo, Wang Qing, Geng Cell Death Dis Review Article Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases. Nature Publishing Group UK 2021-07-23 /pmc/articles/PMC8302660/ /pubmed/34301918 http://dx.doi.org/10.1038/s41419-021-04019-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ning, Li
Rui, Xiong
Bo, Wang
Qing, Geng
The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title_full The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title_fullStr The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title_full_unstemmed The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title_short The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
title_sort critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302660/
https://www.ncbi.nlm.nih.gov/pubmed/34301918
http://dx.doi.org/10.1038/s41419-021-04019-6
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