Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA

Expressed on cells of the myeloid and lymphoid lineages, V-domain Ig Suppressor of T cell Activation (VISTA) is an emerging target for cancer immunotherapy. Blocking VISTA activates both innate and adaptive immunity to eradicate tumors in mice. Using a tripeptide small molecule antagonist of VISTA C...

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Detalles Bibliográficos
Autores principales: Pan, Jing, Chen, Yao, Zhang, Qi, Khatun, Achia, Palen, Katie, Xin, Gang, Wang, Li, Yang, Chuanjia, Johnson, Bryon D., Myers, Charles R., Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, Cui, Weiguo, You, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302676/
https://www.ncbi.nlm.nih.gov/pubmed/34302042
http://dx.doi.org/10.1038/s42003-021-02381-x

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