BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory

BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms and, in some cases, have led to increased adverse even...

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Detalles Bibliográficos
Autores principales: Nash, A., Gijsen, H. J. M., Hrupka, B. J., Teng, K. S.-L., Lichtenthaler, S. F., Takeshima, H., Gunnersen, J. M., Munro, K. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302682/
https://www.ncbi.nlm.nih.gov/pubmed/34302009
http://dx.doi.org/10.1038/s41598-021-94369-0

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