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Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study

Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-...

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Autores principales: Peng, Jiaxin, Yao, Fan, Li, Qiuyu, Ge, Qianmin, Shi, Wenqing, Su, Ting, Tang, Liying, Pan, Yicong, Liang, Rongbin, Zhang, Lijuan, Shao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302749/
https://www.ncbi.nlm.nih.gov/pubmed/34301967
http://dx.doi.org/10.1038/s41598-021-92281-1
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author Peng, Jiaxin
Yao, Fan
Li, Qiuyu
Ge, Qianmin
Shi, Wenqing
Su, Ting
Tang, Liying
Pan, Yicong
Liang, Rongbin
Zhang, Lijuan
Shao, Yi
author_facet Peng, Jiaxin
Yao, Fan
Li, Qiuyu
Ge, Qianmin
Shi, Wenqing
Su, Ting
Tang, Liying
Pan, Yicong
Liang, Rongbin
Zhang, Lijuan
Shao, Yi
author_sort Peng, Jiaxin
collection PubMed
description Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-brain changes of interhemispheric FC in children with strabismus and amblyopia (CSA) using voxel-mirrored homotopic connectivity (VMHC).A total of 24 CSA (16 males and 8 females) and 24 normal controls (NCs) consisting of 16 and 8 age-, sex, and education-matched males and females, respectively, underwent functional magnetic resonance imaging (fMRI) scans in the resting state. According to Gaussian random field theory, changes in the resting state FC (rsFC) between hemispheres were evaluated using the VMHC method. The relationships between mean VMHC values in multiple brain regions and behavioral performance were evaluated by Pearson correlation analysis. In contrast to NCs, the CSA group showed significantly decreased VMHC values in the bilateral cerebellum, bilateral frontal superior orbital (frontal sup orb), bilateral temporal inferior(temporal inf),and bilateral frontal superior(frontal sup). CSA have abnormal interhemispheric FC in many brain regions, which may reflect dysfunction of eye movements and visual fusion. These findings might provide insight into the underlying pathogenetic mechanisms of CSA.
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spelling pubmed-83027492021-07-27 Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study Peng, Jiaxin Yao, Fan Li, Qiuyu Ge, Qianmin Shi, Wenqing Su, Ting Tang, Liying Pan, Yicong Liang, Rongbin Zhang, Lijuan Shao, Yi Sci Rep Article Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-brain changes of interhemispheric FC in children with strabismus and amblyopia (CSA) using voxel-mirrored homotopic connectivity (VMHC).A total of 24 CSA (16 males and 8 females) and 24 normal controls (NCs) consisting of 16 and 8 age-, sex, and education-matched males and females, respectively, underwent functional magnetic resonance imaging (fMRI) scans in the resting state. According to Gaussian random field theory, changes in the resting state FC (rsFC) between hemispheres were evaluated using the VMHC method. The relationships between mean VMHC values in multiple brain regions and behavioral performance were evaluated by Pearson correlation analysis. In contrast to NCs, the CSA group showed significantly decreased VMHC values in the bilateral cerebellum, bilateral frontal superior orbital (frontal sup orb), bilateral temporal inferior(temporal inf),and bilateral frontal superior(frontal sup). CSA have abnormal interhemispheric FC in many brain regions, which may reflect dysfunction of eye movements and visual fusion. These findings might provide insight into the underlying pathogenetic mechanisms of CSA. Nature Publishing Group UK 2021-07-23 /pmc/articles/PMC8302749/ /pubmed/34301967 http://dx.doi.org/10.1038/s41598-021-92281-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Peng, Jiaxin
Yao, Fan
Li, Qiuyu
Ge, Qianmin
Shi, Wenqing
Su, Ting
Tang, Liying
Pan, Yicong
Liang, Rongbin
Zhang, Lijuan
Shao, Yi
Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_full Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_fullStr Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_full_unstemmed Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_short Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_sort alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fmri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302749/
https://www.ncbi.nlm.nih.gov/pubmed/34301967
http://dx.doi.org/10.1038/s41598-021-92281-1
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