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Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement

PURPOSE: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Hence, we investigated whether vitamin C could lower propofol dosage in elderly patients u...

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Autores principales: Li, Yang, Feng, Long, Zhang, Xiaoying, Huang, Lianjun, Song, Jie, Chen, Guoqing, Zhang, Yu, Zhang, Chenggang, Li, Weiguang, Feng, Zeguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302814/
https://www.ncbi.nlm.nih.gov/pubmed/34321919
http://dx.doi.org/10.2147/JPR.S319172
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author Li, Yang
Feng, Long
Zhang, Xiaoying
Huang, Lianjun
Song, Jie
Chen, Guoqing
Zhang, Yu
Zhang, Chenggang
Li, Weiguang
Feng, Zeguo
author_facet Li, Yang
Feng, Long
Zhang, Xiaoying
Huang, Lianjun
Song, Jie
Chen, Guoqing
Zhang, Yu
Zhang, Chenggang
Li, Weiguang
Feng, Zeguo
author_sort Li, Yang
collection PubMed
description PURPOSE: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Hence, we investigated whether vitamin C could lower propofol dosage in elderly patients undergoing total knee replacement surgery. PATIENTS AND METHODS: The trial was carried out in PLA General Hospital in Beijing, China. We enrolled patients aged ≥50 years who were undergoing unilateral total knee arthroplasty with total intravenous anesthesia combined with lumbar sciatic nerve block. The patients were randomly assigned to either the vitamin C (Vc) group (0.067 g/kg) or the control group (an equivalent dose of normal saline). Nerve block was done for all the patients before the general anesthesia. The same depth of anesthesia was maintained during the operation. We compared the propofol dosage and adverse events (eg hypotension) during anesthesia between the two groups. This study was registered with the Chinese Clinical Trial Registry, www.chictr.org.cn, number ChiCTR-TRC-16010112. RESULTS: There were significant differences in the total infusion dose (Vc group: 704.3 ± 188.6 mg; control group: 888.6 ± 232.7 mg; p = 0.016) and the average maintenance dose of propofol (Vc group: 5.8 ± 1.0 mg/kg/h; control group: 6.9 ± 1.6 mg/kg/h; p = 0.013). But there were no significant differences in the induction dose of propofol (control group: 90 mg, range 80–115 mg; Vc group: 100 mg, range 90–110 mg, p = 0.379) between the Vc and control groups. Furthermore, there were no significant differences in the hemodynamics and the incidence of intraoperative hypotension. CONCLUSION: Vitamin C can reduce the dosage of propofol in patients undergoing total knee replacement.
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spelling pubmed-83028142021-07-27 Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement Li, Yang Feng, Long Zhang, Xiaoying Huang, Lianjun Song, Jie Chen, Guoqing Zhang, Yu Zhang, Chenggang Li, Weiguang Feng, Zeguo J Pain Res Original Research PURPOSE: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Hence, we investigated whether vitamin C could lower propofol dosage in elderly patients undergoing total knee replacement surgery. PATIENTS AND METHODS: The trial was carried out in PLA General Hospital in Beijing, China. We enrolled patients aged ≥50 years who were undergoing unilateral total knee arthroplasty with total intravenous anesthesia combined with lumbar sciatic nerve block. The patients were randomly assigned to either the vitamin C (Vc) group (0.067 g/kg) or the control group (an equivalent dose of normal saline). Nerve block was done for all the patients before the general anesthesia. The same depth of anesthesia was maintained during the operation. We compared the propofol dosage and adverse events (eg hypotension) during anesthesia between the two groups. This study was registered with the Chinese Clinical Trial Registry, www.chictr.org.cn, number ChiCTR-TRC-16010112. RESULTS: There were significant differences in the total infusion dose (Vc group: 704.3 ± 188.6 mg; control group: 888.6 ± 232.7 mg; p = 0.016) and the average maintenance dose of propofol (Vc group: 5.8 ± 1.0 mg/kg/h; control group: 6.9 ± 1.6 mg/kg/h; p = 0.013). But there were no significant differences in the induction dose of propofol (control group: 90 mg, range 80–115 mg; Vc group: 100 mg, range 90–110 mg, p = 0.379) between the Vc and control groups. Furthermore, there were no significant differences in the hemodynamics and the incidence of intraoperative hypotension. CONCLUSION: Vitamin C can reduce the dosage of propofol in patients undergoing total knee replacement. Dove 2021-07-19 /pmc/articles/PMC8302814/ /pubmed/34321919 http://dx.doi.org/10.2147/JPR.S319172 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Yang
Feng, Long
Zhang, Xiaoying
Huang, Lianjun
Song, Jie
Chen, Guoqing
Zhang, Yu
Zhang, Chenggang
Li, Weiguang
Feng, Zeguo
Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title_full Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title_fullStr Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title_full_unstemmed Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title_short Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement
title_sort intraoperative vitamin c reduces the dosage of propofol in patients undergoing total knee replacement
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302814/
https://www.ncbi.nlm.nih.gov/pubmed/34321919
http://dx.doi.org/10.2147/JPR.S319172
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