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Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems

This study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for CVD and to identify the most useful NAFLD diagnostic tool for predicting CVD. Data from a total of 23,376 Korean adults without established CVD were analyzed. Cardiovascular risk was calc...

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Autores principales: Kweon, Ye-Na, Ko, Hae-Jin, Kim, A-Sol, Choi, Hye-In, Song, Ji-Eun, Park, Ji-Yeon, Kim, Sung-Min, Hong, Hee-Eun, Min, Kyung-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303122/
https://www.ncbi.nlm.nih.gov/pubmed/34356275
http://dx.doi.org/10.3390/healthcare9070899
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author Kweon, Ye-Na
Ko, Hae-Jin
Kim, A-Sol
Choi, Hye-In
Song, Ji-Eun
Park, Ji-Yeon
Kim, Sung-Min
Hong, Hee-Eun
Min, Kyung-Jin
author_facet Kweon, Ye-Na
Ko, Hae-Jin
Kim, A-Sol
Choi, Hye-In
Song, Ji-Eun
Park, Ji-Yeon
Kim, Sung-Min
Hong, Hee-Eun
Min, Kyung-Jin
author_sort Kweon, Ye-Na
collection PubMed
description This study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for CVD and to identify the most useful NAFLD diagnostic tool for predicting CVD. Data from a total of 23,376 Korean adults without established CVD were analyzed. Cardiovascular risk was calculated using the Framingham Risk Score (FRS) 2008. The presence of NAFLD was defined as moderate-to-severe fatty liver disease diagnosed by ultrasonography. Scores for fatty liver were calculated using four NAFLD scoring systems (Fatty Liver Index, FLI; Hepatic Steatosis Index, HSI; Simple NAFLD Score, SNS; Comprehensive NAFLD Score, CNS), and were compared and analyzed according to cardiovascular risk group. Using the FRS, 67.4% of participants were considered to be at low risk of CVD, 21.5% at intermediate risk, and 11.1% at high risk. As the risk of CVD increased, both the prevalence of NAFLD and the score from each NAFLD scoring system increased significantly (p < 0.001). In the unadjusted analysis, the CNS had the strongest association with high CVD risk; in the adjusted analysis, the FLI score was most strongly associated with high CVD risk. Fatty liver is an important independent risk factor for CVD. Therefore, the available NAFLD scoring systems could be utilized to predict CVD.
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spelling pubmed-83031222021-07-25 Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems Kweon, Ye-Na Ko, Hae-Jin Kim, A-Sol Choi, Hye-In Song, Ji-Eun Park, Ji-Yeon Kim, Sung-Min Hong, Hee-Eun Min, Kyung-Jin Healthcare (Basel) Article This study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for CVD and to identify the most useful NAFLD diagnostic tool for predicting CVD. Data from a total of 23,376 Korean adults without established CVD were analyzed. Cardiovascular risk was calculated using the Framingham Risk Score (FRS) 2008. The presence of NAFLD was defined as moderate-to-severe fatty liver disease diagnosed by ultrasonography. Scores for fatty liver were calculated using four NAFLD scoring systems (Fatty Liver Index, FLI; Hepatic Steatosis Index, HSI; Simple NAFLD Score, SNS; Comprehensive NAFLD Score, CNS), and were compared and analyzed according to cardiovascular risk group. Using the FRS, 67.4% of participants were considered to be at low risk of CVD, 21.5% at intermediate risk, and 11.1% at high risk. As the risk of CVD increased, both the prevalence of NAFLD and the score from each NAFLD scoring system increased significantly (p < 0.001). In the unadjusted analysis, the CNS had the strongest association with high CVD risk; in the adjusted analysis, the FLI score was most strongly associated with high CVD risk. Fatty liver is an important independent risk factor for CVD. Therefore, the available NAFLD scoring systems could be utilized to predict CVD. MDPI 2021-07-15 /pmc/articles/PMC8303122/ /pubmed/34356275 http://dx.doi.org/10.3390/healthcare9070899 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kweon, Ye-Na
Ko, Hae-Jin
Kim, A-Sol
Choi, Hye-In
Song, Ji-Eun
Park, Ji-Yeon
Kim, Sung-Min
Hong, Hee-Eun
Min, Kyung-Jin
Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title_full Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title_fullStr Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title_full_unstemmed Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title_short Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
title_sort prediction of cardiovascular risk using nonalcoholic fatty liver disease scoring systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303122/
https://www.ncbi.nlm.nih.gov/pubmed/34356275
http://dx.doi.org/10.3390/healthcare9070899
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