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Identifying a Common Functional Framework for Apathy Large-Scale Brain Network

Apathy is a neuropsychiatric condition characterized by reduced motivation, initiative, and interest in daily life activities, and it is commonly reported in several neurodegenerative disorders. The study aims to investigate large-scale brain networks involved in apathy syndrome in patients with fro...

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Autores principales: Alfano, Vincenzo, Longarzo, Mariachiara, Mele, Giulia, Esposito, Marcello, Aiello, Marco, Salvatore, Marco, Grossi, Dario, Cavaliere, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303126/
https://www.ncbi.nlm.nih.gov/pubmed/34357146
http://dx.doi.org/10.3390/jpm11070679
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author Alfano, Vincenzo
Longarzo, Mariachiara
Mele, Giulia
Esposito, Marcello
Aiello, Marco
Salvatore, Marco
Grossi, Dario
Cavaliere, Carlo
author_facet Alfano, Vincenzo
Longarzo, Mariachiara
Mele, Giulia
Esposito, Marcello
Aiello, Marco
Salvatore, Marco
Grossi, Dario
Cavaliere, Carlo
author_sort Alfano, Vincenzo
collection PubMed
description Apathy is a neuropsychiatric condition characterized by reduced motivation, initiative, and interest in daily life activities, and it is commonly reported in several neurodegenerative disorders. The study aims to investigate large-scale brain networks involved in apathy syndrome in patients with frontotemporal dementia (FTD) and Parkinson’s disease (PD) compared to a group of healthy controls (HC). The study sample includes a total of 60 subjects: 20 apathetic FTD and PD patients, 20 non apathetic FTD and PD patients, and 20 HC matched for age. Two disease-specific apathy-evaluation scales were used to measure the presence of apathy in FTD and PD patients; in the same day, a 3T brain magnetic resonance imaging (MRI) with structural and resting-state functional (fMRI) sequences was acquired. Differences in functional connectivity (FC) were assessed between apathetic and non-apathetic patients with and without primary clinical diagnosis revealed, using a whole-brain, seed-to-seed approach. A significant hypoconnectivity between apathetic patients (both FTD and PD) and HC was detected between left planum polare and both right pre- or post-central gyrus. Finally, to investigate whether such neural alterations were due to the underlying neurodegenerative pathology, we replicated the analysis by considering two independent patients’ samples (i.e., non-apathetic PD and FTD). In these groups, functional differences were no longer detected. These alterations may subtend the involvement of neural pathways implicated in a specific reduction of information/elaboration processing and motor outcome in apathetic patients.
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spelling pubmed-83031262021-07-25 Identifying a Common Functional Framework for Apathy Large-Scale Brain Network Alfano, Vincenzo Longarzo, Mariachiara Mele, Giulia Esposito, Marcello Aiello, Marco Salvatore, Marco Grossi, Dario Cavaliere, Carlo J Pers Med Article Apathy is a neuropsychiatric condition characterized by reduced motivation, initiative, and interest in daily life activities, and it is commonly reported in several neurodegenerative disorders. The study aims to investigate large-scale brain networks involved in apathy syndrome in patients with frontotemporal dementia (FTD) and Parkinson’s disease (PD) compared to a group of healthy controls (HC). The study sample includes a total of 60 subjects: 20 apathetic FTD and PD patients, 20 non apathetic FTD and PD patients, and 20 HC matched for age. Two disease-specific apathy-evaluation scales were used to measure the presence of apathy in FTD and PD patients; in the same day, a 3T brain magnetic resonance imaging (MRI) with structural and resting-state functional (fMRI) sequences was acquired. Differences in functional connectivity (FC) were assessed between apathetic and non-apathetic patients with and without primary clinical diagnosis revealed, using a whole-brain, seed-to-seed approach. A significant hypoconnectivity between apathetic patients (both FTD and PD) and HC was detected between left planum polare and both right pre- or post-central gyrus. Finally, to investigate whether such neural alterations were due to the underlying neurodegenerative pathology, we replicated the analysis by considering two independent patients’ samples (i.e., non-apathetic PD and FTD). In these groups, functional differences were no longer detected. These alterations may subtend the involvement of neural pathways implicated in a specific reduction of information/elaboration processing and motor outcome in apathetic patients. MDPI 2021-07-19 /pmc/articles/PMC8303126/ /pubmed/34357146 http://dx.doi.org/10.3390/jpm11070679 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alfano, Vincenzo
Longarzo, Mariachiara
Mele, Giulia
Esposito, Marcello
Aiello, Marco
Salvatore, Marco
Grossi, Dario
Cavaliere, Carlo
Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title_full Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title_fullStr Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title_full_unstemmed Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title_short Identifying a Common Functional Framework for Apathy Large-Scale Brain Network
title_sort identifying a common functional framework for apathy large-scale brain network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303126/
https://www.ncbi.nlm.nih.gov/pubmed/34357146
http://dx.doi.org/10.3390/jpm11070679
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