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Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)

The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health c...

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Autores principales: Okutsu, Shota, Kato, Yoshifumi, Funakoshi, Shunsuke, Maeda, Toshiki, Yoshimura, Chikara, Kawazoe, Miki, Satoh, Atsushi, Yokota, Soichiro, Tada, Kazuhiro, Takahashi, Koji, Ito, Kenji, Yasuno, Tetsuhiko, Fujii, Hideyuki, Mukoubara, Shigeaki, Nakashima, Hitoshi, Kawanami, Daiji, Masutani, Kosuke, Arima, Hisatomi, Nabeshima, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303188/
https://www.ncbi.nlm.nih.gov/pubmed/34300264
http://dx.doi.org/10.3390/jcm10143098
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author Okutsu, Shota
Kato, Yoshifumi
Funakoshi, Shunsuke
Maeda, Toshiki
Yoshimura, Chikara
Kawazoe, Miki
Satoh, Atsushi
Yokota, Soichiro
Tada, Kazuhiro
Takahashi, Koji
Ito, Kenji
Yasuno, Tetsuhiko
Fujii, Hideyuki
Mukoubara, Shigeaki
Nakashima, Hitoshi
Kawanami, Daiji
Masutani, Kosuke
Arima, Hisatomi
Nabeshima, Shigeki
author_facet Okutsu, Shota
Kato, Yoshifumi
Funakoshi, Shunsuke
Maeda, Toshiki
Yoshimura, Chikara
Kawazoe, Miki
Satoh, Atsushi
Yokota, Soichiro
Tada, Kazuhiro
Takahashi, Koji
Ito, Kenji
Yasuno, Tetsuhiko
Fujii, Hideyuki
Mukoubara, Shigeaki
Nakashima, Hitoshi
Kawanami, Daiji
Masutani, Kosuke
Arima, Hisatomi
Nabeshima, Shigeki
author_sort Okutsu, Shota
collection PubMed
description The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, p = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese.
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spelling pubmed-83031882021-07-25 Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) Okutsu, Shota Kato, Yoshifumi Funakoshi, Shunsuke Maeda, Toshiki Yoshimura, Chikara Kawazoe, Miki Satoh, Atsushi Yokota, Soichiro Tada, Kazuhiro Takahashi, Koji Ito, Kenji Yasuno, Tetsuhiko Fujii, Hideyuki Mukoubara, Shigeaki Nakashima, Hitoshi Kawanami, Daiji Masutani, Kosuke Arima, Hisatomi Nabeshima, Shigeki J Clin Med Article The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, p = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese. MDPI 2021-07-14 /pmc/articles/PMC8303188/ /pubmed/34300264 http://dx.doi.org/10.3390/jcm10143098 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okutsu, Shota
Kato, Yoshifumi
Funakoshi, Shunsuke
Maeda, Toshiki
Yoshimura, Chikara
Kawazoe, Miki
Satoh, Atsushi
Yokota, Soichiro
Tada, Kazuhiro
Takahashi, Koji
Ito, Kenji
Yasuno, Tetsuhiko
Fujii, Hideyuki
Mukoubara, Shigeaki
Nakashima, Hitoshi
Kawanami, Daiji
Masutani, Kosuke
Arima, Hisatomi
Nabeshima, Shigeki
Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title_full Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title_fullStr Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title_full_unstemmed Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title_short Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
title_sort effects of weight gain after 20 years of age and incidence of hyper-low-density lipoprotein cholesterolemia: the iki epidemiological study of atherosclerosis and chronic kidney disease (issa-ckd)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303188/
https://www.ncbi.nlm.nih.gov/pubmed/34300264
http://dx.doi.org/10.3390/jcm10143098
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