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Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters

Background: Neurologic symptom severity and deterioration at 24 hours (h) predict long-term outcomes in patients with acute large vessel occlusion (LVO) stroke of the anterior circulation. We aimed to examine the association of baseline multiparametric CT imaging and clinical factors with the course...

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Autores principales: Fabritius, Matthias Philipp, Wölfer, Teresa A., Herzberg, Moriz, Tiedt, Steffen, Puhr-Westerheide, Daniel, Grosu, Sergio, Maurus, Stefan, Geyer, Thomas, Curta, Adrian, Kellert, Lars, Küpper, Clemens, Liebig, Thomas, Ricke, Jens, Dimitriadis, Konstantinos, Kunz, Wolfgang G., Zimmermann, Hanna, Reidler, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303279/
https://www.ncbi.nlm.nih.gov/pubmed/34359354
http://dx.doi.org/10.3390/diagnostics11071272
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author Fabritius, Matthias Philipp
Wölfer, Teresa A.
Herzberg, Moriz
Tiedt, Steffen
Puhr-Westerheide, Daniel
Grosu, Sergio
Maurus, Stefan
Geyer, Thomas
Curta, Adrian
Kellert, Lars
Küpper, Clemens
Liebig, Thomas
Ricke, Jens
Dimitriadis, Konstantinos
Kunz, Wolfgang G.
Zimmermann, Hanna
Reidler, Paul
author_facet Fabritius, Matthias Philipp
Wölfer, Teresa A.
Herzberg, Moriz
Tiedt, Steffen
Puhr-Westerheide, Daniel
Grosu, Sergio
Maurus, Stefan
Geyer, Thomas
Curta, Adrian
Kellert, Lars
Küpper, Clemens
Liebig, Thomas
Ricke, Jens
Dimitriadis, Konstantinos
Kunz, Wolfgang G.
Zimmermann, Hanna
Reidler, Paul
author_sort Fabritius, Matthias Philipp
collection PubMed
description Background: Neurologic symptom severity and deterioration at 24 hours (h) predict long-term outcomes in patients with acute large vessel occlusion (LVO) stroke of the anterior circulation. We aimed to examine the association of baseline multiparametric CT imaging and clinical factors with the course of neurologic symptom severity in the first 24 h after endovascular treatment (EVT). Methods: Patients with LVO stroke of the anterior circulation were selected from a prospectively acquired consecutive cohort of patients who underwent multiparametric CT, including non-contrast CT, CT angiography and CT perfusion before EVT. The symptom severity was assessed on admission and after 24 h using the 42-point National Institutes of Health Stroke Scale (NIHSS). Clinical and imaging data were compared between patients with and without early neurological deterioration (END). END was defined as an increase in ≥4 points, and a significant clinical improvement as a decrease in ≥4 points, compared to NIHSS on admission. Multivariate regression analyses were used to determine independent associations of imaging and clinical parameters with NIHSS score increase or decrease in the first 24 h. Results: A total of 211 patients were included, of whom 38 (18.0%) had an END. END was significantly associated with occlusion of the internal carotid artery (odds ratio (OR), 4.25; 95% CI, 1.90–9.47) and the carotid T (OR, 6.34; 95% CI, 2.56–15.71), clot burden score (OR, 0.79; 95% CI, 0.68–0.92) and total ischemic volume (OR, 1.01; 95% CI, 1.00–1.01). In a comprehensive multivariate analysis model including periprocedural parameters and complications after EVT, carotid T occlusion remained independently associated with END, next to reperfusion status and intracranial hemorrhage. Favorable reperfusion status and small ischemic core volume were associated with clinical improvement after 24 h. Conclusions: The use of imaging parameters as a surrogate for early NIHSS progression in an acute LVO stroke after EVT reached limited performance with only carotid T occlusion as an independent predictor of END. Reperfusion status and early complications in terms of intracranial hemorrhage are critical factors that influence patient outcome in the acute stroke phase after EVT.
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spelling pubmed-83032792021-07-25 Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters Fabritius, Matthias Philipp Wölfer, Teresa A. Herzberg, Moriz Tiedt, Steffen Puhr-Westerheide, Daniel Grosu, Sergio Maurus, Stefan Geyer, Thomas Curta, Adrian Kellert, Lars Küpper, Clemens Liebig, Thomas Ricke, Jens Dimitriadis, Konstantinos Kunz, Wolfgang G. Zimmermann, Hanna Reidler, Paul Diagnostics (Basel) Article Background: Neurologic symptom severity and deterioration at 24 hours (h) predict long-term outcomes in patients with acute large vessel occlusion (LVO) stroke of the anterior circulation. We aimed to examine the association of baseline multiparametric CT imaging and clinical factors with the course of neurologic symptom severity in the first 24 h after endovascular treatment (EVT). Methods: Patients with LVO stroke of the anterior circulation were selected from a prospectively acquired consecutive cohort of patients who underwent multiparametric CT, including non-contrast CT, CT angiography and CT perfusion before EVT. The symptom severity was assessed on admission and after 24 h using the 42-point National Institutes of Health Stroke Scale (NIHSS). Clinical and imaging data were compared between patients with and without early neurological deterioration (END). END was defined as an increase in ≥4 points, and a significant clinical improvement as a decrease in ≥4 points, compared to NIHSS on admission. Multivariate regression analyses were used to determine independent associations of imaging and clinical parameters with NIHSS score increase or decrease in the first 24 h. Results: A total of 211 patients were included, of whom 38 (18.0%) had an END. END was significantly associated with occlusion of the internal carotid artery (odds ratio (OR), 4.25; 95% CI, 1.90–9.47) and the carotid T (OR, 6.34; 95% CI, 2.56–15.71), clot burden score (OR, 0.79; 95% CI, 0.68–0.92) and total ischemic volume (OR, 1.01; 95% CI, 1.00–1.01). In a comprehensive multivariate analysis model including periprocedural parameters and complications after EVT, carotid T occlusion remained independently associated with END, next to reperfusion status and intracranial hemorrhage. Favorable reperfusion status and small ischemic core volume were associated with clinical improvement after 24 h. Conclusions: The use of imaging parameters as a surrogate for early NIHSS progression in an acute LVO stroke after EVT reached limited performance with only carotid T occlusion as an independent predictor of END. Reperfusion status and early complications in terms of intracranial hemorrhage are critical factors that influence patient outcome in the acute stroke phase after EVT. MDPI 2021-07-15 /pmc/articles/PMC8303279/ /pubmed/34359354 http://dx.doi.org/10.3390/diagnostics11071272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fabritius, Matthias Philipp
Wölfer, Teresa A.
Herzberg, Moriz
Tiedt, Steffen
Puhr-Westerheide, Daniel
Grosu, Sergio
Maurus, Stefan
Geyer, Thomas
Curta, Adrian
Kellert, Lars
Küpper, Clemens
Liebig, Thomas
Ricke, Jens
Dimitriadis, Konstantinos
Kunz, Wolfgang G.
Zimmermann, Hanna
Reidler, Paul
Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title_full Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title_fullStr Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title_full_unstemmed Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title_short Course of Early Neurologic Symptom Severity after Endovascular Treatment of Anterior Circulation Large Vessel Occlusion Stroke: Association with Baseline Multiparametric CT Imaging and Clinical Parameters
title_sort course of early neurologic symptom severity after endovascular treatment of anterior circulation large vessel occlusion stroke: association with baseline multiparametric ct imaging and clinical parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303279/
https://www.ncbi.nlm.nih.gov/pubmed/34359354
http://dx.doi.org/10.3390/diagnostics11071272
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