Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Efflux transporters, namely ATP-binding cassette (ABC), are one of the primary reasons for cancer chemoresistance and the clinical failure of chemotherapy. Ganciclovir (GCV) is an antiviral agent used in herpes simplex virus thymidine kinase (HSV-TK) gene therapy. In this therapy, HSV-TK gene is del...

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Detalles Bibliográficos
Autores principales: Markowicz-Piasecka, Magdalena, Huttunen, Johanna, Montaser, Ahmed, Adla, Santosh Kumar, Auriola, Seppo, Lehtonen, Marko, Huttunen, Kristiina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303380/
https://www.ncbi.nlm.nih.gov/pubmed/34299347
http://dx.doi.org/10.3390/ijms22147727

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