Proteogenomics Reveals Orthologous Alternatively Spliced Proteoforms in the Same Human and Mouse Brain Regions with Differential Abundance in an Alzheimer’s Disease Mouse Model

Alternative splicing (AS) may increase the number of proteoforms produced by a gene. Alzheimer’s disease (AD) is a neurodegenerative disease with well-characterized AS proteoforms. In this study, we used a proteogenomics strategy to build a customized protein sequence database and identify orthologo...

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Detalles Bibliográficos
Autores principales: da Silva, Esdras Matheus Gomes, Santos, Letícia Graziela Costa, de Oliveira, Flávia Santiago, Freitas, Flávia Cristina de Paula, Parreira, Vinícius da Silva Coutinho, dos Santos, Hellen Geremias, Tavares, Raphael, Carvalho, Paulo Costa, Neves-Ferreira, Ana Gisele da Costa, Haibara, Andrea Siqueira, de Araujo-Souza, Patrícia Savio, Dias, Adriana Abalen Martins, Passetti, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303486/
https://www.ncbi.nlm.nih.gov/pubmed/34201730
http://dx.doi.org/10.3390/cells10071583

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