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Proteogenomics Reveals Orthologous Alternatively Spliced Proteoforms in the Same Human and Mouse Brain Regions with Differential Abundance in an Alzheimer’s Disease Mouse Model
Alternative splicing (AS) may increase the number of proteoforms produced by a gene. Alzheimer’s disease (AD) is a neurodegenerative disease with well-characterized AS proteoforms. In this study, we used a proteogenomics strategy to build a customized protein sequence database and identify orthologo...
Autores principales: | da Silva, Esdras Matheus Gomes, Santos, Letícia Graziela Costa, de Oliveira, Flávia Santiago, Freitas, Flávia Cristina de Paula, Parreira, Vinícius da Silva Coutinho, dos Santos, Hellen Geremias, Tavares, Raphael, Carvalho, Paulo Costa, Neves-Ferreira, Ana Gisele da Costa, Haibara, Andrea Siqueira, de Araujo-Souza, Patrícia Savio, Dias, Adriana Abalen Martins, Passetti, Fabio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303486/ https://www.ncbi.nlm.nih.gov/pubmed/34201730 http://dx.doi.org/10.3390/cells10071583 |
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