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Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures
This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-grou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303545/ https://www.ncbi.nlm.nih.gov/pubmed/34299556 http://dx.doi.org/10.3390/molecules26144281 |
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author | Mousavifar, Leila Abdullayev, Shuay Roy, René |
author_facet | Mousavifar, Leila Abdullayev, Shuay Roy, René |
author_sort | Mousavifar, Leila |
collection | PubMed |
description | This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-group and two hydrophobic lipid tails embedded in the lipid bilayers of the cell membranes, they usually require extraneous lipids (phosphatidylcholine, cholesterol) to confer their stability. In order to obviate the necessity for these additional stabilizing ingredients, recent investigations have merged dendrimer chemistry with that of neoglycolipid syntheses. This singular approach has provided novel glycoarchitectures allowing reconsidering the necessity for the traditional one to two hydrophilic/hydrophobic ratio. An emphasis has been provided in the recent design of modular arborescent neoglycolipid syntheses coined glycodendrimersomes. |
format | Online Article Text |
id | pubmed-8303545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83035452021-07-25 Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures Mousavifar, Leila Abdullayev, Shuay Roy, René Molecules Review This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-group and two hydrophobic lipid tails embedded in the lipid bilayers of the cell membranes, they usually require extraneous lipids (phosphatidylcholine, cholesterol) to confer their stability. In order to obviate the necessity for these additional stabilizing ingredients, recent investigations have merged dendrimer chemistry with that of neoglycolipid syntheses. This singular approach has provided novel glycoarchitectures allowing reconsidering the necessity for the traditional one to two hydrophilic/hydrophobic ratio. An emphasis has been provided in the recent design of modular arborescent neoglycolipid syntheses coined glycodendrimersomes. MDPI 2021-07-15 /pmc/articles/PMC8303545/ /pubmed/34299556 http://dx.doi.org/10.3390/molecules26144281 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mousavifar, Leila Abdullayev, Shuay Roy, René Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title | Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title_full | Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title_fullStr | Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title_full_unstemmed | Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title_short | Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures |
title_sort | recent development in the design of neoglycoliposomes bearing arborescent architectures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303545/ https://www.ncbi.nlm.nih.gov/pubmed/34299556 http://dx.doi.org/10.3390/molecules26144281 |
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