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The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer
Dynamic modifications on RNA, frequently termed both, “RNA epigenetics” and “epitranscriptomics”, offer one of the most exciting emerging areas of gene regulation and biomedicine. Similar to chromatin-based epigenetic mechanisms, writers, readers, and erasers regulate both the presence and interpret...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303600/ https://www.ncbi.nlm.nih.gov/pubmed/34209046 http://dx.doi.org/10.3390/genes12071019 |
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author | Maldonado López, Alexandra Capell, Brian C. |
author_facet | Maldonado López, Alexandra Capell, Brian C. |
author_sort | Maldonado López, Alexandra |
collection | PubMed |
description | Dynamic modifications on RNA, frequently termed both, “RNA epigenetics” and “epitranscriptomics”, offer one of the most exciting emerging areas of gene regulation and biomedicine. Similar to chromatin-based epigenetic mechanisms, writers, readers, and erasers regulate both the presence and interpretation of these modifications, thereby adding further nuance to the control of gene expression. In particular, the most abundant modification on mRNAs, N(6)-methyladenosine (m(6)A), catalyzed by methyltransferase-like 3 (METTL3) has been shown to play a critical role in self-renewing somatic epithelia, fine-tuning the balance between development, differentiation, and cancer, particularly in the case of squamous cell carcinomas (SCCs), which in aggregate, outnumber all other human cancers. Along with the development of targeted inhibitors of epitranscriptomic modulators (e.g., METTL3) now entering clinical trials, the field holds significant promise for treating these abundant cancers. Here, we present the most current summary of this work, while also highlighting the therapeutic potential of these discoveries. |
format | Online Article Text |
id | pubmed-8303600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83036002021-07-25 The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer Maldonado López, Alexandra Capell, Brian C. Genes (Basel) Review Dynamic modifications on RNA, frequently termed both, “RNA epigenetics” and “epitranscriptomics”, offer one of the most exciting emerging areas of gene regulation and biomedicine. Similar to chromatin-based epigenetic mechanisms, writers, readers, and erasers regulate both the presence and interpretation of these modifications, thereby adding further nuance to the control of gene expression. In particular, the most abundant modification on mRNAs, N(6)-methyladenosine (m(6)A), catalyzed by methyltransferase-like 3 (METTL3) has been shown to play a critical role in self-renewing somatic epithelia, fine-tuning the balance between development, differentiation, and cancer, particularly in the case of squamous cell carcinomas (SCCs), which in aggregate, outnumber all other human cancers. Along with the development of targeted inhibitors of epitranscriptomic modulators (e.g., METTL3) now entering clinical trials, the field holds significant promise for treating these abundant cancers. Here, we present the most current summary of this work, while also highlighting the therapeutic potential of these discoveries. MDPI 2021-06-30 /pmc/articles/PMC8303600/ /pubmed/34209046 http://dx.doi.org/10.3390/genes12071019 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maldonado López, Alexandra Capell, Brian C. The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title | The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title_full | The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title_fullStr | The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title_full_unstemmed | The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title_short | The METTL3-m(6)A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer |
title_sort | mettl3-m(6)a epitranscriptome: dynamic regulator of epithelial development, differentiation, and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303600/ https://www.ncbi.nlm.nih.gov/pubmed/34209046 http://dx.doi.org/10.3390/genes12071019 |
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