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Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury
In the general population, serial imaging is recommended over anticoagulant therapy for below-knee deep vein thrombosis (BKDVT). However, no clinical trial in Asian patients with spinal cord injury and BKDVT has been performed. Therefore, we evaluated the natural course of BKDVT in patients with acu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303622/ https://www.ncbi.nlm.nih.gov/pubmed/34356239 http://dx.doi.org/10.3390/healthcare9070861 |
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author | Cho, Jang-Hyuk Lee, Dong-Gyu |
author_facet | Cho, Jang-Hyuk Lee, Dong-Gyu |
author_sort | Cho, Jang-Hyuk |
collection | PubMed |
description | In the general population, serial imaging is recommended over anticoagulant therapy for below-knee deep vein thrombosis (BKDVT). However, no clinical trial in Asian patients with spinal cord injury and BKDVT has been performed. Therefore, we evaluated the natural course of BKDVT in patients with acute spinal cord injury. We retrospectively analyzed inpatients with spinal cord injury with BKDVT between 2016 and 2020. All patients underwent inpatient rehabilitation treatment and duplex ultrasonographic examination of both the lower extremities at follow-up. After screening 172 patients with acute spinal cord injury for deep vein thrombosis using duplex ultrasound, 27 patients with below-the-knee deep vein thrombosis were included in this study. The mean lower-extremity motor score (median, interquartile range) was 66.0, 54.0–74.5. Sixteen patients received a non-vitamin K antagonist oral anticoagulant (NOAC) for anticoagulation. None of the patients had proximal propagation according to the follow-up duplex ultrasonography. BKDVT disappearance was not significantly different between the NOAC treatment and non-treatment groups. Asian patients with spinal cord injury have a low incidence of venous thromboembolism and favorable natural history of BKDVT. We recommend serial imaging over anticoagulant therapy for BKDVT in these patients. |
format | Online Article Text |
id | pubmed-8303622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83036222021-07-25 Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury Cho, Jang-Hyuk Lee, Dong-Gyu Healthcare (Basel) Article In the general population, serial imaging is recommended over anticoagulant therapy for below-knee deep vein thrombosis (BKDVT). However, no clinical trial in Asian patients with spinal cord injury and BKDVT has been performed. Therefore, we evaluated the natural course of BKDVT in patients with acute spinal cord injury. We retrospectively analyzed inpatients with spinal cord injury with BKDVT between 2016 and 2020. All patients underwent inpatient rehabilitation treatment and duplex ultrasonographic examination of both the lower extremities at follow-up. After screening 172 patients with acute spinal cord injury for deep vein thrombosis using duplex ultrasound, 27 patients with below-the-knee deep vein thrombosis were included in this study. The mean lower-extremity motor score (median, interquartile range) was 66.0, 54.0–74.5. Sixteen patients received a non-vitamin K antagonist oral anticoagulant (NOAC) for anticoagulation. None of the patients had proximal propagation according to the follow-up duplex ultrasonography. BKDVT disappearance was not significantly different between the NOAC treatment and non-treatment groups. Asian patients with spinal cord injury have a low incidence of venous thromboembolism and favorable natural history of BKDVT. We recommend serial imaging over anticoagulant therapy for BKDVT in these patients. MDPI 2021-07-08 /pmc/articles/PMC8303622/ /pubmed/34356239 http://dx.doi.org/10.3390/healthcare9070861 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cho, Jang-Hyuk Lee, Dong-Gyu Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title | Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title_full | Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title_fullStr | Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title_full_unstemmed | Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title_short | Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury |
title_sort | natural history of isolated below-knee vein thrombosis in patients with spinal cord injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303622/ https://www.ncbi.nlm.nih.gov/pubmed/34356239 http://dx.doi.org/10.3390/healthcare9070861 |
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