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Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor

More than 80% of colorectal cancer patients have adenomatous polyposis coli (APC) mutations, which induce abnormal WNT/β-catenin activation. Tankyrase (TNKS) mediates the release of active β-catenin, which occurs regardless of the ligand that translocates into the nucleus by AXIN degradation via the...

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Detalles Bibliográficos
Autores principales:	Ryu, Hwani, Nam, Ky-Youb, Kim, Hyo Jeong, Song, Jie-Young, Hwang, Sang-Gu, Kim, Jae Sung, Kim, Joon, Ahn, Jiyeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303674/ https://www.ncbi.nlm.nih.gov/pubmed/34298950 http://dx.doi.org/10.3390/ijms22147330

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