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The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin
Cucurbit[7]uril (CB[7]) is a molecular container that may form host–guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]–oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303694/ https://www.ncbi.nlm.nih.gov/pubmed/34298956 http://dx.doi.org/10.3390/ijms22147337 |
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author | Pashkina, Ekaterina Aktanova, Alina Mirzaeva, Irina Kovalenko, Ekaterina Andrienko, Irina Knauer, Nadezhda Pronkina, Natalya Kozlov, Vladimir |
author_facet | Pashkina, Ekaterina Aktanova, Alina Mirzaeva, Irina Kovalenko, Ekaterina Andrienko, Irina Knauer, Nadezhda Pronkina, Natalya Kozlov, Vladimir |
author_sort | Pashkina, Ekaterina |
collection | PubMed |
description | Cucurbit[7]uril (CB[7]) is a molecular container that may form host–guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]–oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability and proliferation of a primary cell culture (peripheral blood mononuclear cells), two tumor cell lines (B16 and K562) and their activity in the animal model of melanoma. At the same time, we studied the impact of platinum (II) drugs with CB[7] on T cells and B cells in vitro. Although the stable CB[7]–carboplatin complex was not formed, the presence of cucurbit[7]uril affected the biological properties of carboplatin. In vivo, CB[7] increased the antitumor effect of carboplatin, but, at the same time, increased its acute toxicity. Compared to free oxaliplatin, its complex with CB[7] shows a greater cytotoxic effect on tumor cell lines B16 and K562, while in vivo, the effects of the free drug and encapsulated drug were comparable. However, in vivo studies also demonstrated that the encapsulation of oxaliplatin in CB[7] lowered the toxicity of the drug. |
format | Online Article Text |
id | pubmed-8303694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83036942021-07-25 The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin Pashkina, Ekaterina Aktanova, Alina Mirzaeva, Irina Kovalenko, Ekaterina Andrienko, Irina Knauer, Nadezhda Pronkina, Natalya Kozlov, Vladimir Int J Mol Sci Article Cucurbit[7]uril (CB[7]) is a molecular container that may form host–guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]–oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability and proliferation of a primary cell culture (peripheral blood mononuclear cells), two tumor cell lines (B16 and K562) and their activity in the animal model of melanoma. At the same time, we studied the impact of platinum (II) drugs with CB[7] on T cells and B cells in vitro. Although the stable CB[7]–carboplatin complex was not formed, the presence of cucurbit[7]uril affected the biological properties of carboplatin. In vivo, CB[7] increased the antitumor effect of carboplatin, but, at the same time, increased its acute toxicity. Compared to free oxaliplatin, its complex with CB[7] shows a greater cytotoxic effect on tumor cell lines B16 and K562, while in vivo, the effects of the free drug and encapsulated drug were comparable. However, in vivo studies also demonstrated that the encapsulation of oxaliplatin in CB[7] lowered the toxicity of the drug. MDPI 2021-07-08 /pmc/articles/PMC8303694/ /pubmed/34298956 http://dx.doi.org/10.3390/ijms22147337 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pashkina, Ekaterina Aktanova, Alina Mirzaeva, Irina Kovalenko, Ekaterina Andrienko, Irina Knauer, Nadezhda Pronkina, Natalya Kozlov, Vladimir The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title | The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title_full | The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title_fullStr | The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title_full_unstemmed | The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title_short | The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin |
title_sort | effect of cucurbit[7]uril on the antitumor and immunomodulating properties of oxaliplatin and carboplatin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303694/ https://www.ncbi.nlm.nih.gov/pubmed/34298956 http://dx.doi.org/10.3390/ijms22147337 |
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