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The Influence of Virus Infection on Microglia and Accelerated Brain Aging
Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infecti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303900/ https://www.ncbi.nlm.nih.gov/pubmed/34360004 http://dx.doi.org/10.3390/cells10071836 |
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author | Filgueira, Luis Larionov, Alexey Lannes, Nils |
author_facet | Filgueira, Luis Larionov, Alexey Lannes, Nils |
author_sort | Filgueira, Luis |
collection | PubMed |
description | Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging. |
format | Online Article Text |
id | pubmed-8303900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83039002021-07-25 The Influence of Virus Infection on Microglia and Accelerated Brain Aging Filgueira, Luis Larionov, Alexey Lannes, Nils Cells Review Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging. MDPI 2021-07-20 /pmc/articles/PMC8303900/ /pubmed/34360004 http://dx.doi.org/10.3390/cells10071836 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Filgueira, Luis Larionov, Alexey Lannes, Nils The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title | The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title_full | The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title_fullStr | The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title_full_unstemmed | The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title_short | The Influence of Virus Infection on Microglia and Accelerated Brain Aging |
title_sort | influence of virus infection on microglia and accelerated brain aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303900/ https://www.ncbi.nlm.nih.gov/pubmed/34360004 http://dx.doi.org/10.3390/cells10071836 |
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