The Influence of Virus Infection on Microglia and Accelerated Brain Aging

Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Filgueira, Luis, Larionov, Alexey, Lannes, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303900/
https://www.ncbi.nlm.nih.gov/pubmed/34360004
http://dx.doi.org/10.3390/cells10071836
_version_ 1783727201063010304
author Filgueira, Luis
Larionov, Alexey
Lannes, Nils
author_facet Filgueira, Luis
Larionov, Alexey
Lannes, Nils
author_sort Filgueira, Luis
collection PubMed
description Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
format Online
Article
Text
id pubmed-8303900
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83039002021-07-25 The Influence of Virus Infection on Microglia and Accelerated Brain Aging Filgueira, Luis Larionov, Alexey Lannes, Nils Cells Review Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging. MDPI 2021-07-20 /pmc/articles/PMC8303900/ /pubmed/34360004 http://dx.doi.org/10.3390/cells10071836 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Filgueira, Luis
Larionov, Alexey
Lannes, Nils
The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title_full The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title_fullStr The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title_full_unstemmed The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title_short The Influence of Virus Infection on Microglia and Accelerated Brain Aging
title_sort influence of virus infection on microglia and accelerated brain aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303900/
https://www.ncbi.nlm.nih.gov/pubmed/34360004
http://dx.doi.org/10.3390/cells10071836
work_keys_str_mv AT filgueiraluis theinfluenceofvirusinfectiononmicrogliaandacceleratedbrainaging
AT larionovalexey theinfluenceofvirusinfectiononmicrogliaandacceleratedbrainaging
AT lannesnils theinfluenceofvirusinfectiononmicrogliaandacceleratedbrainaging
AT filgueiraluis influenceofvirusinfectiononmicrogliaandacceleratedbrainaging
AT larionovalexey influenceofvirusinfectiononmicrogliaandacceleratedbrainaging
AT lannesnils influenceofvirusinfectiononmicrogliaandacceleratedbrainaging

Ejemplares similares