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Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients

Obesity, as a major risk factor of metabolic syndrome (MetS), represents a pandemic, especially in Western societies, and is considered a risk factor for malignancies. Helicobacter pylori (Hp), is a definite carcinogen with global distribution. We aimed to investigate, for the first time in Switzerl...

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Autores principales: Doulberis, Michael, Pierre, Noah Thierry, Manzini, Giulia, Papaefthymiou, Apostolis, Kountouras, Jannis, Klukowska-Rötzler, Jolanta, Polyzos, Stergios A., Srivastava, Simone, Exadaktylos, Aristomenis K., Knuchel, Jürg, Kuntzen, Thomas, Srivastava, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303942/
https://www.ncbi.nlm.nih.gov/pubmed/34201748
http://dx.doi.org/10.3390/microorganisms9071361
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author Doulberis, Michael
Pierre, Noah Thierry
Manzini, Giulia
Papaefthymiou, Apostolis
Kountouras, Jannis
Klukowska-Rötzler, Jolanta
Polyzos, Stergios A.
Srivastava, Simone
Exadaktylos, Aristomenis K.
Knuchel, Jürg
Kuntzen, Thomas
Srivastava, David S.
author_facet Doulberis, Michael
Pierre, Noah Thierry
Manzini, Giulia
Papaefthymiou, Apostolis
Kountouras, Jannis
Klukowska-Rötzler, Jolanta
Polyzos, Stergios A.
Srivastava, Simone
Exadaktylos, Aristomenis K.
Knuchel, Jürg
Kuntzen, Thomas
Srivastava, David S.
author_sort Doulberis, Michael
collection PubMed
description Obesity, as a major risk factor of metabolic syndrome (MetS), represents a pandemic, especially in Western societies, and is considered a risk factor for malignancies. Helicobacter pylori (Hp), is a definite carcinogen with global distribution. We aimed to investigate, for the first time in Switzerland, the main gastric mucosa premalignant histological lesions of bariatric patients in correlation with MetS components and Hp Infection (Hp-I). By reviewing retrospectively 94304 patient cases, a total of 116 eligible patients having undergone bariatric surgery were identified. The mean patient age was 48.66 years. Hp(+) patients were 24% (28/116). Presence of gastric mucosa atrophy was documented in 8/28 Hp(+) patients (29%) and (2/88) Hp(−) ones (2%) (p = 0.006). Gastric mucosa intestinal metaplasia was observed in 14/28 (50%) Hp(+) patients versus 3/88 (3.4%) of Hp(-) group (p < 0.0001). Hp(+) patients exhibited statistically higher arterial hypertension (p = 0.033). The homeostatic model of assessment insulin resistance was also statistically significantly higher for the Hp(+) group (p < 0.001). In a multivariate analysis, including arterial hypertension, gastric mucosa atrophy, and intestinal metaplasia as variables, statistical significance remained only for intestinal metaplasia (p = 0.001). In conclusion, Hp-I is associated with premalignant gastric mucosa histologic lesions and MetS components, including arterial hypertension and IR. Further large-scale prospective studies are required to confirm these findings.
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spelling pubmed-83039422021-07-25 Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients Doulberis, Michael Pierre, Noah Thierry Manzini, Giulia Papaefthymiou, Apostolis Kountouras, Jannis Klukowska-Rötzler, Jolanta Polyzos, Stergios A. Srivastava, Simone Exadaktylos, Aristomenis K. Knuchel, Jürg Kuntzen, Thomas Srivastava, David S. Microorganisms Article Obesity, as a major risk factor of metabolic syndrome (MetS), represents a pandemic, especially in Western societies, and is considered a risk factor for malignancies. Helicobacter pylori (Hp), is a definite carcinogen with global distribution. We aimed to investigate, for the first time in Switzerland, the main gastric mucosa premalignant histological lesions of bariatric patients in correlation with MetS components and Hp Infection (Hp-I). By reviewing retrospectively 94304 patient cases, a total of 116 eligible patients having undergone bariatric surgery were identified. The mean patient age was 48.66 years. Hp(+) patients were 24% (28/116). Presence of gastric mucosa atrophy was documented in 8/28 Hp(+) patients (29%) and (2/88) Hp(−) ones (2%) (p = 0.006). Gastric mucosa intestinal metaplasia was observed in 14/28 (50%) Hp(+) patients versus 3/88 (3.4%) of Hp(-) group (p < 0.0001). Hp(+) patients exhibited statistically higher arterial hypertension (p = 0.033). The homeostatic model of assessment insulin resistance was also statistically significantly higher for the Hp(+) group (p < 0.001). In a multivariate analysis, including arterial hypertension, gastric mucosa atrophy, and intestinal metaplasia as variables, statistical significance remained only for intestinal metaplasia (p = 0.001). In conclusion, Hp-I is associated with premalignant gastric mucosa histologic lesions and MetS components, including arterial hypertension and IR. Further large-scale prospective studies are required to confirm these findings. MDPI 2021-06-23 /pmc/articles/PMC8303942/ /pubmed/34201748 http://dx.doi.org/10.3390/microorganisms9071361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Doulberis, Michael
Pierre, Noah Thierry
Manzini, Giulia
Papaefthymiou, Apostolis
Kountouras, Jannis
Klukowska-Rötzler, Jolanta
Polyzos, Stergios A.
Srivastava, Simone
Exadaktylos, Aristomenis K.
Knuchel, Jürg
Kuntzen, Thomas
Srivastava, David S.
Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title_full Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title_fullStr Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title_full_unstemmed Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title_short Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients
title_sort helicobacter pylori-related metabolic parameters and premalignant gastric mucosa histological lesions in swiss bariatric patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303942/
https://www.ncbi.nlm.nih.gov/pubmed/34201748
http://dx.doi.org/10.3390/microorganisms9071361
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