Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer

Known as a key effector in breast cancer (BC) progression, calcium (Ca(2+)) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca(2+) channels are the main actors among Ca(2+) transporters that control the intracellular Ca(2+) concentration in cells. It is well known that the basal Ca(2+) concentration is regulated by both store-dependent and independent Ca(2+) channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca(2+) entry, and only a few studies are focusing on store-independent Ca(2+) entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field.