Cargando…

Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux

SIMPLE SUMMARY: Innate and acquired platinum resistance are the leading causes of epithelial ovarian cancer (EOC) mortality. However, the mechanisms remain elusive. Here we found that Exo70, a key subunit of the exocyst, is upregulated in EOC and promotes cisplatin efflux to facilitate innate resist...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yujie, Hong, Xiaoting, Chen, Xiong, Hu, Chun, Lu, Weihong, Xie, Baoying, Zhong, Linhai, Zhang, Wenqing, Cao, Hanwei, Chen, Binbin, Liu, Qian, Zhan, Yanyan, Xiao, Li, Hu, Tianhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304026/ https://www.ncbi.nlm.nih.gov/pubmed/34298686 http://dx.doi.org/10.3390/cancers13143467

Ejemplares similares

ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
por: Mao, Liyuan, et al.
Publicado: (2020)

Exo70 is an independent prognostic factor in colon cancer
por: Xiao, Li, et al.
Publicado: (2017)

Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells
por: Zhao, Yujie, et al.
Publicado: (2016)

Active Efflux System for Cisplatin in Cisplatin‐resistant Human KB Cells
por: Fujii, Ryu‐ichi, et al.
Publicado: (1994)

FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer
por: Zhou, Jinhua, et al.
Publicado: (2014)

Exo-Functionalized Metallacages as Host-Guest Systems for the Anticancer Drug Cisplatin
por: Woods, Ben, et al.
Publicado: (2019)

The role of Exo70 in vascular smooth muscle cell migration
por: Ma, Wenqing, et al.
Publicado: (2016)

Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin
por: Gupta, A., et al.
Publicado: (2022)

Paclitaxel and SN‐38 Overcome Cisplatin Resistance of Ovarian Cancer Cell Lines by Down‐regulating the Influx and Efflux System of Cisplatin
por: Komuro, Yuuki, et al.
Publicado: (2001)

The role for the exocyst complex subunits Exo70B2 and Exo70H1 in the plant–pathogen interaction
por: Pečenková, Tamara, et al.
Publicado: (2011)

N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics
por: Casinelli, Gabriella, et al.
Publicado: (2016)

Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin
por: Cai, J, et al.
Publicado: (2013)

Multi-drug-resistance efflux in cisplatin-naive and cisplatin-exposed A2780 ovarian cancer cells responds differently to cell culture dimensionality
por: Koshkin, Vasilij, et al.
Publicado: (2021)

Aberrant ROS Served as an Acquired Vulnerability of Cisplatin-Resistant Lung Cancer
por: Xin, Qian, et al.
Publicado: (2022)

Functional Specialization within the EXO70 Gene Family in Arabidopsis
por: Marković, Vedrana, et al.
Publicado: (2021)

Exocyst Subunits Exo70 and Exo84 Cooperate with Small GTPases to Regulate Behavior and Endocytic Trafficking in C. elegans
por: Jiu, Yaming, et al.
Publicado: (2012)

miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells
por: Lin, Chen, et al.
Publicado: (2018)

Disruption of OsEXO70A1 Causes Irregular Vascular Bundles and Perturbs Mineral Nutrient Assimilation in Rice
por: Tu, Bin, et al.
Publicado: (2015)

Correction: Exocyst Subunits Exo70 and Exo84 Cooperate with Small GTPases to Regulate Behavior and Endocytic Trafficking in C. elegans
por: Jiu, Yaming, et al.
Publicado: (2012)

Nab-Paclitaxel in combination with Cisplatin Versus Docetaxel Plus Cisplatin as First-Line Therapy in Non-small Cell Lung Cancer
por: Chen, Yi, et al.
Publicado: (2017)

Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells.
por: Kondo, S., et al.
Publicado: (1995)

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α
por: Hong, Xiaoting, et al.
Publicado: (2019)

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer
por: Li, Dandan, et al.
Publicado: (2018)

Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence
por: Iram, Sana, et al.
Publicado: (2019)

Identification and Characterization of the EXO70 Gene Family in Polyploid Wheat and Related Species
por: Zhao, Jia, et al.
Publicado: (2018)

GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery
por: Rohena, Cristina, et al.
Publicado: (2020)

Exo70 intracellular redistribution after repeated mild traumatic brain injury
por: Lira, Matías, et al.
Publicado: (2021)

Identification and Comprehensive Structural and Functional Analyses of the EXO70 Gene Family in Cotton
por: Zhu, Ya-Qian, et al.
Publicado: (2021)

Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells
por: SHEN, LUYAN, et al.
Publicado: (2016)

Piperlongumine increases the sensitivity of bladder cancer to cisplatin by mitochondrial ROS
por: Pan, Xiaobo, et al.
Publicado: (2022)

Concurrent weekly single cisplatin vs triweekly cisplatin alone with radiotherapy for treatment of locally advanced cervical cancer: a meta-analysis
por: Zhu, Jiahao, et al.
Publicado: (2018)

Cisplatin-resistant HepG2 cell-derived exosomes transfer cisplatin resistance to cisplatin-sensitive cells in HCC
por: Tang, Zuxiong, et al.
Publicado: (2021)

The EXO70 inhibitor Endosidin2 alters plasma membrane protein composition in Arabidopsis roots
por: Li, Xiaohui, et al.
Publicado: (2023)

Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins
por: Steinlein, Sophia, et al.
Publicado: (2023)

Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70
por: Endo, H, et al.
Publicado: (2014)

Genome-wide identification and expression analysis of the EXO70 gene family in grape (Vitis vinifera L)
por: Wang, Han, et al.
Publicado: (2021)

Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells
por: Sun, Xilong, et al.
Publicado: (2017)

Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
por: Hu, Xiaoru, et al.
Publicado: (2021)

PD‐0332991 combined with cisplatin inhibits nonsmall cell lung cancer and reversal of cisplatin resistance
por: Liu, Minghui, et al.
Publicado: (2021)

Exo70 Subunit of the Exocyst Complex Is Involved in Adhesion-Dependent Trafficking of Caveolin-1
por: Hertzog, Maud, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kkmkv0u3oh905amef1u9j3k3os