Cargando…
Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-pe...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304030/ https://www.ncbi.nlm.nih.gov/pubmed/34357347 http://dx.doi.org/10.3390/metabo11070453 |
_version_ | 1783727234814574592 |
---|---|
author | Mantovani, Alessandro Dalbeni, Andrea Peserico, Denise Cattazzo, Filippo Bevilacqua, Michele Salvagno, Gian Luca Lippi, Giuseppe Targher, Giovanni Danese, Elisa Fava, Cristiano |
author_facet | Mantovani, Alessandro Dalbeni, Andrea Peserico, Denise Cattazzo, Filippo Bevilacqua, Michele Salvagno, Gian Luca Lippi, Giuseppe Targher, Giovanni Danese, Elisa Fava, Cristiano |
author_sort | Mantovani, Alessandro |
collection | PubMed |
description | A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, p = 0.005) and secondary BAs (standardized β coefficient: 0.508, p < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; p < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, p = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, p = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM. |
format | Online Article Text |
id | pubmed-8304030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83040302021-07-25 Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes Mantovani, Alessandro Dalbeni, Andrea Peserico, Denise Cattazzo, Filippo Bevilacqua, Michele Salvagno, Gian Luca Lippi, Giuseppe Targher, Giovanni Danese, Elisa Fava, Cristiano Metabolites Article A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, p = 0.005) and secondary BAs (standardized β coefficient: 0.508, p < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; p < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, p = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, p = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM. MDPI 2021-07-14 /pmc/articles/PMC8304030/ /pubmed/34357347 http://dx.doi.org/10.3390/metabo11070453 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mantovani, Alessandro Dalbeni, Andrea Peserico, Denise Cattazzo, Filippo Bevilacqua, Michele Salvagno, Gian Luca Lippi, Giuseppe Targher, Giovanni Danese, Elisa Fava, Cristiano Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title_full | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title_fullStr | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title_full_unstemmed | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title_short | Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes |
title_sort | plasma bile acid profile in patients with and without type 2 diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304030/ https://www.ncbi.nlm.nih.gov/pubmed/34357347 http://dx.doi.org/10.3390/metabo11070453 |
work_keys_str_mv | AT mantovanialessandro plasmabileacidprofileinpatientswithandwithouttype2diabetes AT dalbeniandrea plasmabileacidprofileinpatientswithandwithouttype2diabetes AT pesericodenise plasmabileacidprofileinpatientswithandwithouttype2diabetes AT cattazzofilippo plasmabileacidprofileinpatientswithandwithouttype2diabetes AT bevilacquamichele plasmabileacidprofileinpatientswithandwithouttype2diabetes AT salvagnogianluca plasmabileacidprofileinpatientswithandwithouttype2diabetes AT lippigiuseppe plasmabileacidprofileinpatientswithandwithouttype2diabetes AT targhergiovanni plasmabileacidprofileinpatientswithandwithouttype2diabetes AT daneseelisa plasmabileacidprofileinpatientswithandwithouttype2diabetes AT favacristiano plasmabileacidprofileinpatientswithandwithouttype2diabetes |