Cargando…

Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes

A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Mantovani, Alessandro, Dalbeni, Andrea, Peserico, Denise, Cattazzo, Filippo, Bevilacqua, Michele, Salvagno, Gian Luca, Lippi, Giuseppe, Targher, Giovanni, Danese, Elisa, Fava, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304030/
https://www.ncbi.nlm.nih.gov/pubmed/34357347
http://dx.doi.org/10.3390/metabo11070453
_version_ 1783727234814574592
author Mantovani, Alessandro
Dalbeni, Andrea
Peserico, Denise
Cattazzo, Filippo
Bevilacqua, Michele
Salvagno, Gian Luca
Lippi, Giuseppe
Targher, Giovanni
Danese, Elisa
Fava, Cristiano
author_facet Mantovani, Alessandro
Dalbeni, Andrea
Peserico, Denise
Cattazzo, Filippo
Bevilacqua, Michele
Salvagno, Gian Luca
Lippi, Giuseppe
Targher, Giovanni
Danese, Elisa
Fava, Cristiano
author_sort Mantovani, Alessandro
collection PubMed
description A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, p = 0.005) and secondary BAs (standardized β coefficient: 0.508, p < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; p < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, p = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, p = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM.
format Online
Article
Text
id pubmed-8304030
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83040302021-07-25 Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes Mantovani, Alessandro Dalbeni, Andrea Peserico, Denise Cattazzo, Filippo Bevilacqua, Michele Salvagno, Gian Luca Lippi, Giuseppe Targher, Giovanni Danese, Elisa Fava, Cristiano Metabolites Article A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, p = 0.005) and secondary BAs (standardized β coefficient: 0.508, p < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; p < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, p = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, p = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM. MDPI 2021-07-14 /pmc/articles/PMC8304030/ /pubmed/34357347 http://dx.doi.org/10.3390/metabo11070453 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mantovani, Alessandro
Dalbeni, Andrea
Peserico, Denise
Cattazzo, Filippo
Bevilacqua, Michele
Salvagno, Gian Luca
Lippi, Giuseppe
Targher, Giovanni
Danese, Elisa
Fava, Cristiano
Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title_full Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title_fullStr Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title_full_unstemmed Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title_short Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
title_sort plasma bile acid profile in patients with and without type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304030/
https://www.ncbi.nlm.nih.gov/pubmed/34357347
http://dx.doi.org/10.3390/metabo11070453
work_keys_str_mv AT mantovanialessandro plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT dalbeniandrea plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT pesericodenise plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT cattazzofilippo plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT bevilacquamichele plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT salvagnogianluca plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT lippigiuseppe plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT targhergiovanni plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT daneseelisa plasmabileacidprofileinpatientswithandwithouttype2diabetes
AT favacristiano plasmabileacidprofileinpatientswithandwithouttype2diabetes