Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated. All samples were extracted using acetonitrile for protein precipitation and analyzed using the u...

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Detalles Bibliográficos
Autores principales: Pookmanee, Waritda, Thongthip, Siriwan, Tankanitlert, Jeeranut, Mungthin, Mathirut, Sukasem, Chonlaphat, Wittayalertpanya, Supeecha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304466/
https://www.ncbi.nlm.nih.gov/pubmed/34299634
http://dx.doi.org/10.3390/molecules26144357

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