Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone

An 85-year-old women with transthyretin cardiac amyloidosis presented with generalized weakness, elevated liver function test levels, and creatinine kinase consistent with rhabdomyolysis 1 week after starting tafamidis. She was already taking atorvastatin and amiodarone, raising the possibility of a...

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Detalles Bibliográficos
Autores principales: Laird, Jessica, Falk, Rodney H., Coyle, Melissa, Cuddy, Sarah A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Mini-Focus Issue: Heart Failure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304530/
https://www.ncbi.nlm.nih.gov/pubmed/34317174
http://dx.doi.org/10.1016/j.jaccas.2020.09.037
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author Laird, Jessica
Falk, Rodney H.
Coyle, Melissa
Cuddy, Sarah A.M.
author_facet Laird, Jessica
Falk, Rodney H.
Coyle, Melissa
Cuddy, Sarah A.M.
author_sort Laird, Jessica
collection PubMed
description An 85-year-old women with transthyretin cardiac amyloidosis presented with generalized weakness, elevated liver function test levels, and creatinine kinase consistent with rhabdomyolysis 1 week after starting tafamidis. She was already taking atorvastatin and amiodarone, raising the possibility of a drug–drug interaction inhibiting the breakdown and excretion of atorvastatin, causing drug-induced rhabdomyolysis. (Level of Difficulty: Intermediate.)
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spelling pubmed-83045302021-07-26 Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone Laird, Jessica Falk, Rodney H. Coyle, Melissa Cuddy, Sarah A.M. JACC Case Rep Mini-Focus Issue: Heart Failure An 85-year-old women with transthyretin cardiac amyloidosis presented with generalized weakness, elevated liver function test levels, and creatinine kinase consistent with rhabdomyolysis 1 week after starting tafamidis. She was already taking atorvastatin and amiodarone, raising the possibility of a drug–drug interaction inhibiting the breakdown and excretion of atorvastatin, causing drug-induced rhabdomyolysis. (Level of Difficulty: Intermediate.) Elsevier 2020-12-02 /pmc/articles/PMC8304530/ /pubmed/34317174 http://dx.doi.org/10.1016/j.jaccas.2020.09.037 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue: Heart Failure
Laird, Jessica
Falk, Rodney H.
Coyle, Melissa
Cuddy, Sarah A.M.
Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title_full Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title_fullStr Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title_full_unstemmed Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title_short Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone
title_sort rhabdomyolysis in the setting of concomitant use of tafamidis, atorvastatin, and amiodarone
topic Mini-Focus Issue: Heart Failure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304530/
https://www.ncbi.nlm.nih.gov/pubmed/34317174
http://dx.doi.org/10.1016/j.jaccas.2020.09.037
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