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Modelling Nuclear Morphology and Shape Transformation: A Review

As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated...

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Autores principales: Fang, Chao, Yao, Jiaxing, Xia, Xingyu, Lin, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304582/
https://www.ncbi.nlm.nih.gov/pubmed/34357190
http://dx.doi.org/10.3390/membranes11070540
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author Fang, Chao
Yao, Jiaxing
Xia, Xingyu
Lin, Yuan
author_facet Fang, Chao
Yao, Jiaxing
Xia, Xingyu
Lin, Yuan
author_sort Fang, Chao
collection PubMed
description As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated that the morphology change of NE is tightly related to nuclear mechanotransduction and the pathogenesis of diseases such as cancer and Hutchinson–Gilford Progeria Syndrome. Theoretically, with the help of well-designed experiments, significant progress has been made in understanding the physical mechanisms behind nuclear shape transformation in different cellular processes as well as its biological implications. Here, we review different continuum-level (i.e., energy minimization, boundary integral and finite element-based) approaches that have been developed to predict the morphology and shape change of the cell nucleus. Essential gradients, relative advantages and limitations of each model will be discussed in detail, with the hope of sparking a greater research interest in this important topic in the future.
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spelling pubmed-83045822021-07-25 Modelling Nuclear Morphology and Shape Transformation: A Review Fang, Chao Yao, Jiaxing Xia, Xingyu Lin, Yuan Membranes (Basel) Review As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated that the morphology change of NE is tightly related to nuclear mechanotransduction and the pathogenesis of diseases such as cancer and Hutchinson–Gilford Progeria Syndrome. Theoretically, with the help of well-designed experiments, significant progress has been made in understanding the physical mechanisms behind nuclear shape transformation in different cellular processes as well as its biological implications. Here, we review different continuum-level (i.e., energy minimization, boundary integral and finite element-based) approaches that have been developed to predict the morphology and shape change of the cell nucleus. Essential gradients, relative advantages and limitations of each model will be discussed in detail, with the hope of sparking a greater research interest in this important topic in the future. MDPI 2021-07-16 /pmc/articles/PMC8304582/ /pubmed/34357190 http://dx.doi.org/10.3390/membranes11070540 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fang, Chao
Yao, Jiaxing
Xia, Xingyu
Lin, Yuan
Modelling Nuclear Morphology and Shape Transformation: A Review
title Modelling Nuclear Morphology and Shape Transformation: A Review
title_full Modelling Nuclear Morphology and Shape Transformation: A Review
title_fullStr Modelling Nuclear Morphology and Shape Transformation: A Review
title_full_unstemmed Modelling Nuclear Morphology and Shape Transformation: A Review
title_short Modelling Nuclear Morphology and Shape Transformation: A Review
title_sort modelling nuclear morphology and shape transformation: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304582/
https://www.ncbi.nlm.nih.gov/pubmed/34357190
http://dx.doi.org/10.3390/membranes11070540
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