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Modelling Nuclear Morphology and Shape Transformation: A Review
As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304582/ https://www.ncbi.nlm.nih.gov/pubmed/34357190 http://dx.doi.org/10.3390/membranes11070540 |
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author | Fang, Chao Yao, Jiaxing Xia, Xingyu Lin, Yuan |
author_facet | Fang, Chao Yao, Jiaxing Xia, Xingyu Lin, Yuan |
author_sort | Fang, Chao |
collection | PubMed |
description | As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated that the morphology change of NE is tightly related to nuclear mechanotransduction and the pathogenesis of diseases such as cancer and Hutchinson–Gilford Progeria Syndrome. Theoretically, with the help of well-designed experiments, significant progress has been made in understanding the physical mechanisms behind nuclear shape transformation in different cellular processes as well as its biological implications. Here, we review different continuum-level (i.e., energy minimization, boundary integral and finite element-based) approaches that have been developed to predict the morphology and shape change of the cell nucleus. Essential gradients, relative advantages and limitations of each model will be discussed in detail, with the hope of sparking a greater research interest in this important topic in the future. |
format | Online Article Text |
id | pubmed-8304582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83045822021-07-25 Modelling Nuclear Morphology and Shape Transformation: A Review Fang, Chao Yao, Jiaxing Xia, Xingyu Lin, Yuan Membranes (Basel) Review As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated that the morphology change of NE is tightly related to nuclear mechanotransduction and the pathogenesis of diseases such as cancer and Hutchinson–Gilford Progeria Syndrome. Theoretically, with the help of well-designed experiments, significant progress has been made in understanding the physical mechanisms behind nuclear shape transformation in different cellular processes as well as its biological implications. Here, we review different continuum-level (i.e., energy minimization, boundary integral and finite element-based) approaches that have been developed to predict the morphology and shape change of the cell nucleus. Essential gradients, relative advantages and limitations of each model will be discussed in detail, with the hope of sparking a greater research interest in this important topic in the future. MDPI 2021-07-16 /pmc/articles/PMC8304582/ /pubmed/34357190 http://dx.doi.org/10.3390/membranes11070540 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fang, Chao Yao, Jiaxing Xia, Xingyu Lin, Yuan Modelling Nuclear Morphology and Shape Transformation: A Review |
title | Modelling Nuclear Morphology and Shape Transformation: A Review |
title_full | Modelling Nuclear Morphology and Shape Transformation: A Review |
title_fullStr | Modelling Nuclear Morphology and Shape Transformation: A Review |
title_full_unstemmed | Modelling Nuclear Morphology and Shape Transformation: A Review |
title_short | Modelling Nuclear Morphology and Shape Transformation: A Review |
title_sort | modelling nuclear morphology and shape transformation: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304582/ https://www.ncbi.nlm.nih.gov/pubmed/34357190 http://dx.doi.org/10.3390/membranes11070540 |
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