Cargando…

Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of Bis(Indolyl)Pyridines Analogues of the Marine Alkaloid Nortopsentin

An efficient and simple protocol for the synthesis of a new class of diverse bis(indolyl)pyridines analogues of the marine alkaloid nortopsentin has been reported. A one-pot four-component condensation of 3-cyanocarbomethylindole, various aldehyde, 3-acetylindole, and ammonium acetate in glacial ace...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abo-Salem, Heba M., Abd El Salam, Hayam A., Abdel-Aziem, Anhar M., Abdel-Aziz, Mohamed S., El-Sawy, Eslam Reda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304590/ https://www.ncbi.nlm.nih.gov/pubmed/34299385 http://dx.doi.org/10.3390/molecules26144112

Ejemplares similares

Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin
por: Carbone, Anna, et al.
Publicado: (2013)

Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues
por: Carbone, Anna, et al.
Publicado: (2015)

Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2020)

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2018)

Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety
por: Sayed, Mariam T., et al.
Publicado: (2023)

Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs
por: Spanò, Virginia, et al.
Publicado: (2016)

3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, Nortopsentin Analogues with Antiproliferative Activity
por: Parrino, Barbara, et al.
Publicado: (2015)

Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids
por: Ittiamornkul, Kuljira, et al.
Publicado: (2015)

Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer
por: El-Sawy, Eslam R., et al.
Publicado: (2022)

Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents
por: Elmorsy, Mohamed R., et al.
Publicado: (2022)

Synthesis and biological activity of novel series of 4-methoxy, and 4,9-dimethoxy-5-substituted furo[2,3-g]-1,2,3-benzoxathiazine-7,7-dioxide derivatives
por: El-Sawy, Eslam R., et al.
Publicado: (2014)

New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity
por: Cascioferro, Stella, et al.
Publicado: (2019)

CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin
por: Di Franco, Simone, et al.
Publicado: (2021)

Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development
por: Pecoraro, Camilla, et al.
Publicado: (2023)

Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part 1: Five-Membered Aromatic Rings with One Heteroatom
por: El-Sawy, Eslam Reda, et al.
Publicado: (2021)

Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part II: Five-Membered Aromatic Rings with Multi Heteroatoms
por: El-Sawy, Eslam Reda, et al.
Publicado: (2021)

Insight on Mercapto-Coumarins: Synthesis and Reactivity
por: El-Sawy, Eslam Reda, et al.
Publicado: (2022)

Design, Synthesis, Characterization, and Insecticidal Bioefficacy Screening of Some New Pyridine Derivatives
por: El-Dean, Adel M. Kamal, et al.
Publicado: (2019)

Genetic similarity and diversity among three camel populations reared in Egypt
por: Abdel-Aziem, Sekena H., et al.
Publicado: (2022)

Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, and Molecular Docking Studies of Novel 1H-3-Indolyl Derivatives as Significant Antioxidants
por: Aziz, Maged A., et al.
Publicado: (2021)

Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds
por: Elganzory, Hussein H., et al.
Publicado: (2022)

Evaluation of the alleviative role of Chlorella vulgaris and Spirulina platensis extract against ovarian dysfunctions induced by monosodium glutamate in mice
por: Abdel-Aziem, Sekena H, et al.
Publicado: (2018)

Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A
por: Amr, Abd El-Galil E., et al.
Publicado: (2020)

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules
por: Elkaeed, Eslam B., et al.
Publicado: (2021)

Novel phthalimide based analogues: design, synthesis, biological evaluation, and molecular docking studies
por: Othman, Ismail M. M., et al.
Publicado: (2019)

Synthesis of bis(indolyl)methanes Catalyzed by Triethylborane
por: Merinos, J. Pablo García, et al.
Publicado: (2015)

Synthesis, characterization, in silico molecular docking, and antibacterial activities of some new nitrogen-heterocyclic analogues based on a p-phenolic unit
por: Hussein, Abdel Haleem M., et al.
Publicado: (2022)

Inoculation with arbuscular mycorrhizal fungi alleviates harmful effects of drought stress on damask rose
por: Abdel-Salam, Eslam, et al.
Publicado: (2018)

Genetic variability of myostatin and prolactin genes in popular goat breeds in Egypt
por: Abdel-Aziem, Sekena H., et al.
Publicado: (2018)

Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
por: Eliwa, Duaa, et al.
Publicado: (2022)

Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies
por: Hussein, Mai E., et al.
Publicado: (2022)

Pyridine alkaloids with activity in the central nervous system
por: Lin, Simon X., et al.
Publicado: (2020)

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity
por: Abdel-Rahman, Adel A.-H., et al.
Publicado: (2021)

Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
por: Panda, S. S., et al.
Publicado: (2009)

Mechanistic duality of indolyl 1,3-heteroatom transposition
por: Lee, Yujin, et al.
Publicado: (2023)

Chitosan Schiff base electrospun fabrication and molecular docking assessment for nonleaching antibacterial nanocomposite production
por: Ali, Eman AboBakr, et al.
Publicado: (2023)

An Overview of Aplysinopsins: Synthesis and Biological Activities
por: El-Sawy, Eslam R., et al.
Publicado: (2023)

Friedel–Crafts Reaction of Acylsilanes: Highly Chemoselective Synthesis of 1-Hydroxy-bis(indolyl)methanes and 1-Silyl-bis(indolyl)methanes Derivatives
por: Li, Qi, et al.
Publicado: (2023)

Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones
por: Santoso, Mardi, et al.
Publicado: (2022)

Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives
por: Zhang, Xuejian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3qickgudo2eip8vuin68r5kuu9