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Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensit...

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Autores principales: Wood, Alexis C., Jensen, Elizabeth T., Bertoni, Alain G., Ramesh, Gautam, Rich, Stephen S., Rotter, Jerome I., Chen, Yii-Der I., Goodarzi, Mark O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304591/
https://www.ncbi.nlm.nih.gov/pubmed/34206745
http://dx.doi.org/10.3390/metabo11070420
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author Wood, Alexis C.
Jensen, Elizabeth T.
Bertoni, Alain G.
Ramesh, Gautam
Rich, Stephen S.
Rotter, Jerome I.
Chen, Yii-Der I.
Goodarzi, Mark O.
author_facet Wood, Alexis C.
Jensen, Elizabeth T.
Bertoni, Alain G.
Ramesh, Gautam
Rich, Stephen S.
Rotter, Jerome I.
Chen, Yii-Der I.
Goodarzi, Mark O.
author_sort Wood, Alexis C.
collection PubMed
description Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.
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spelling pubmed-83045912021-07-25 Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) Wood, Alexis C. Jensen, Elizabeth T. Bertoni, Alain G. Ramesh, Gautam Rich, Stephen S. Rotter, Jerome I. Chen, Yii-Der I. Goodarzi, Mark O. Metabolites Article Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia. MDPI 2021-06-26 /pmc/articles/PMC8304591/ /pubmed/34206745 http://dx.doi.org/10.3390/metabo11070420 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wood, Alexis C.
Jensen, Elizabeth T.
Bertoni, Alain G.
Ramesh, Gautam
Rich, Stephen S.
Rotter, Jerome I.
Chen, Yii-Der I.
Goodarzi, Mark O.
Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title_full Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title_fullStr Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title_full_unstemmed Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title_short Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
title_sort defining the relative role of insulin clearance in early dysglycemia in relation to insulin sensitivity and insulin secretion: the microbiome and insulin longitudinal evaluation study (miles)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304591/
https://www.ncbi.nlm.nih.gov/pubmed/34206745
http://dx.doi.org/10.3390/metabo11070420
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