Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

An efficient synthesis of rac-6-desmethyl-5β–hydroxy-d-secoartemisinin 2, a tricyclic analog of R-(+)-artemisinin 1, was accomplished and the racemate was resolved into the (+)-2b and (−)-2a enantiomers via their Mosher Ester diastereomers. Antimalarial activity resided with only the artemisinin-lik...

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Detalles Bibliográficos
Autores principales: Jahan, Mohamed, Leon, Francisco, Fronczek, Frank R., Elokely, Khaled M., Rimoldi, John, Khan, Shabana I., Avery, Mitchell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304634/
https://www.ncbi.nlm.nih.gov/pubmed/34299438
http://dx.doi.org/10.3390/molecules26144163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304634/
https://www.ncbi.nlm.nih.gov/pubmed/34299438
http://dx.doi.org/10.3390/molecules26144163

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