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Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells
The functionalization of decellularized scaffolds is still challenging because of the recellularization-related limitations, including the finding of the most optimal kind of cell(s) and the best way to control their distribution within the scaffolds to generate native mimicking tissues. That is why...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304639/ https://www.ncbi.nlm.nih.gov/pubmed/34359955 http://dx.doi.org/10.3390/cells10071787 |
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author | Ahmed, Ebtehal Saleh, Tarek Xu, Meifeng |
author_facet | Ahmed, Ebtehal Saleh, Tarek Xu, Meifeng |
author_sort | Ahmed, Ebtehal |
collection | PubMed |
description | The functionalization of decellularized scaffolds is still challenging because of the recellularization-related limitations, including the finding of the most optimal kind of cell(s) and the best way to control their distribution within the scaffolds to generate native mimicking tissues. That is why researchers have been encouraged to study stem cells, in particular, mesenchymal stem cells (MSCs), as alternative cells to repopulate and functionalize the scaffolds properly. MSCs could be obtained from various sources and have therapeutic effects on a wide range of inflammatory/degenerative diseases. Therefore, in this mini-review, we will discuss the benefits using of MSCs for recellularization, the factors affecting their efficiency, and the drawbacks that may need to be overcome to generate bioengineered transplantable organs. |
format | Online Article Text |
id | pubmed-8304639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83046392021-07-25 Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells Ahmed, Ebtehal Saleh, Tarek Xu, Meifeng Cells Review The functionalization of decellularized scaffolds is still challenging because of the recellularization-related limitations, including the finding of the most optimal kind of cell(s) and the best way to control their distribution within the scaffolds to generate native mimicking tissues. That is why researchers have been encouraged to study stem cells, in particular, mesenchymal stem cells (MSCs), as alternative cells to repopulate and functionalize the scaffolds properly. MSCs could be obtained from various sources and have therapeutic effects on a wide range of inflammatory/degenerative diseases. Therefore, in this mini-review, we will discuss the benefits using of MSCs for recellularization, the factors affecting their efficiency, and the drawbacks that may need to be overcome to generate bioengineered transplantable organs. MDPI 2021-07-15 /pmc/articles/PMC8304639/ /pubmed/34359955 http://dx.doi.org/10.3390/cells10071787 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ahmed, Ebtehal Saleh, Tarek Xu, Meifeng Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title | Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title_full | Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title_fullStr | Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title_full_unstemmed | Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title_short | Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells |
title_sort | recellularization of native tissue derived acellular scaffolds with mesenchymal stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304639/ https://www.ncbi.nlm.nih.gov/pubmed/34359955 http://dx.doi.org/10.3390/cells10071787 |
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