The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes

Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this revie...

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Autores principales: Inoue, Ryota, Nishiyama, Kuniyuki, Li, Jinghe, Miyashita, Daisuke, Ono, Masato, Terauchi, Yasuo, Shirakawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304653/
https://www.ncbi.nlm.nih.gov/pubmed/34202521
http://dx.doi.org/10.3390/cells10071589
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author Inoue, Ryota
Nishiyama, Kuniyuki
Li, Jinghe
Miyashita, Daisuke
Ono, Masato
Terauchi, Yasuo
Shirakawa, Jun
author_facet Inoue, Ryota
Nishiyama, Kuniyuki
Li, Jinghe
Miyashita, Daisuke
Ono, Masato
Terauchi, Yasuo
Shirakawa, Jun
author_sort Inoue, Ryota
collection PubMed
description Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes.
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spelling pubmed-83046532021-07-25 The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes Inoue, Ryota Nishiyama, Kuniyuki Li, Jinghe Miyashita, Daisuke Ono, Masato Terauchi, Yasuo Shirakawa, Jun Cells Review Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes. MDPI 2021-06-24 /pmc/articles/PMC8304653/ /pubmed/34202521 http://dx.doi.org/10.3390/cells10071589 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Inoue, Ryota
Nishiyama, Kuniyuki
Li, Jinghe
Miyashita, Daisuke
Ono, Masato
Terauchi, Yasuo
Shirakawa, Jun
The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title_full The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title_fullStr The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title_full_unstemmed The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title_short The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
title_sort feasibility and applicability of stem cell therapy for the cure of type 1 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304653/
https://www.ncbi.nlm.nih.gov/pubmed/34202521
http://dx.doi.org/10.3390/cells10071589
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