Cargando…
Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304780/ https://www.ncbi.nlm.nih.gov/pubmed/34299270 http://dx.doi.org/10.3390/ijms22147650 |
_version_ | 1783727417283575808 |
---|---|
author | Severino, Paolo D’Amato, Andrea Prosperi, Silvia Fanisio, Francesca Birtolo, Lucia Ilaria Costi, Bettina Netti, Lucrezia Chimenti, Cristina Lavalle, Carlo Maestrini, Viviana Mancone, Massimo Fedele, Francesco |
author_facet | Severino, Paolo D’Amato, Andrea Prosperi, Silvia Fanisio, Francesca Birtolo, Lucia Ilaria Costi, Bettina Netti, Lucrezia Chimenti, Cristina Lavalle, Carlo Maestrini, Viviana Mancone, Massimo Fedele, Francesco |
author_sort | Severino, Paolo |
collection | PubMed |
description | Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF and traditional cardiovascular risk factors is known. However, myocardial alterations, as well as pathophysiological mechanisms involved are not completely defined. Under the definition of HFpEF there is a wide spectrum of different myocardial structural alterations. Myocardial hypertrophy and fibrosis, coronary microvascular dysfunction, oxidative stress and inflammation are only some of the main pathological detectable processes. Furthermore, there is a lack of effective pharmacological targets to improve HFpEF patients’ outcomes and risk factors control is the primary and unique approach to treat those patients. Myocardial tissue characterization, through invasive and non-invasive techniques, such as endomyocardial biopsy and cardiac magnetic resonance respectively, may represent the starting point to understand the genetic, molecular and pathophysiological mechanisms underlying this complex syndrome. The correlation between histopathological findings and imaging aspects may be the future challenge for the earlier and large-scale HFpEF diagnosis, in order to plan a specific and effective treatment able to modify the disease’s natural course. |
format | Online Article Text |
id | pubmed-8304780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83047802021-07-25 Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets Severino, Paolo D’Amato, Andrea Prosperi, Silvia Fanisio, Francesca Birtolo, Lucia Ilaria Costi, Bettina Netti, Lucrezia Chimenti, Cristina Lavalle, Carlo Maestrini, Viviana Mancone, Massimo Fedele, Francesco Int J Mol Sci Review Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF and traditional cardiovascular risk factors is known. However, myocardial alterations, as well as pathophysiological mechanisms involved are not completely defined. Under the definition of HFpEF there is a wide spectrum of different myocardial structural alterations. Myocardial hypertrophy and fibrosis, coronary microvascular dysfunction, oxidative stress and inflammation are only some of the main pathological detectable processes. Furthermore, there is a lack of effective pharmacological targets to improve HFpEF patients’ outcomes and risk factors control is the primary and unique approach to treat those patients. Myocardial tissue characterization, through invasive and non-invasive techniques, such as endomyocardial biopsy and cardiac magnetic resonance respectively, may represent the starting point to understand the genetic, molecular and pathophysiological mechanisms underlying this complex syndrome. The correlation between histopathological findings and imaging aspects may be the future challenge for the earlier and large-scale HFpEF diagnosis, in order to plan a specific and effective treatment able to modify the disease’s natural course. MDPI 2021-07-17 /pmc/articles/PMC8304780/ /pubmed/34299270 http://dx.doi.org/10.3390/ijms22147650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Severino, Paolo D’Amato, Andrea Prosperi, Silvia Fanisio, Francesca Birtolo, Lucia Ilaria Costi, Bettina Netti, Lucrezia Chimenti, Cristina Lavalle, Carlo Maestrini, Viviana Mancone, Massimo Fedele, Francesco Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title | Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title_full | Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title_fullStr | Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title_full_unstemmed | Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title_short | Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets |
title_sort | myocardial tissue characterization in heart failure with preserved ejection fraction: from histopathology and cardiac magnetic resonance findings to therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304780/ https://www.ncbi.nlm.nih.gov/pubmed/34299270 http://dx.doi.org/10.3390/ijms22147650 |
work_keys_str_mv | AT severinopaolo myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT damatoandrea myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT prosperisilvia myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT fanisiofrancesca myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT birtololuciailaria myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT costibettina myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT nettilucrezia myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT chimenticristina myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT lavallecarlo myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT maestriniviviana myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT manconemassimo myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets AT fedelefrancesco myocardialtissuecharacterizationinheartfailurewithpreservedejectionfractionfromhistopathologyandcardiacmagneticresonancefindingstotherapeutictargets |