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The Impact of Diet and Exercise on Drug Responses

It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in cardiovascular diseases. However, the physiological changes induced by exercise and a modified diet also have the capa...

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Detalles Bibliográficos
Autores principales: Niederberger, Ellen, Parnham, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304791/
https://www.ncbi.nlm.nih.gov/pubmed/34299312
http://dx.doi.org/10.3390/ijms22147692
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author Niederberger, Ellen
Parnham, Michael J.
author_facet Niederberger, Ellen
Parnham, Michael J.
author_sort Niederberger, Ellen
collection PubMed
description It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in cardiovascular diseases. However, the physiological changes induced by exercise and a modified diet also have the capacity to influence the efficacy and toxicity of several drugs, mainly by affecting different pharmacokinetic mechanisms. This pharmacological plasticity is not clinically relevant in all cases but might play an important role in altering the effects of very common drugs, particularly drugs with a narrow therapeutic window. Therefore, with this review, we provide insights into possible food–drug and exercise–drug interactions to sharpen awareness of the potential occurrence of such effects.
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spelling pubmed-83047912021-07-25 The Impact of Diet and Exercise on Drug Responses Niederberger, Ellen Parnham, Michael J. Int J Mol Sci Review It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in cardiovascular diseases. However, the physiological changes induced by exercise and a modified diet also have the capacity to influence the efficacy and toxicity of several drugs, mainly by affecting different pharmacokinetic mechanisms. This pharmacological plasticity is not clinically relevant in all cases but might play an important role in altering the effects of very common drugs, particularly drugs with a narrow therapeutic window. Therefore, with this review, we provide insights into possible food–drug and exercise–drug interactions to sharpen awareness of the potential occurrence of such effects. MDPI 2021-07-19 /pmc/articles/PMC8304791/ /pubmed/34299312 http://dx.doi.org/10.3390/ijms22147692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Niederberger, Ellen
Parnham, Michael J.
The Impact of Diet and Exercise on Drug Responses
title The Impact of Diet and Exercise on Drug Responses
title_full The Impact of Diet and Exercise on Drug Responses
title_fullStr The Impact of Diet and Exercise on Drug Responses
title_full_unstemmed The Impact of Diet and Exercise on Drug Responses
title_short The Impact of Diet and Exercise on Drug Responses
title_sort impact of diet and exercise on drug responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304791/
https://www.ncbi.nlm.nih.gov/pubmed/34299312
http://dx.doi.org/10.3390/ijms22147692
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