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Gene Transcription as a Therapeutic Target in Leukemia
Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional mac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304797/ https://www.ncbi.nlm.nih.gov/pubmed/34298959 http://dx.doi.org/10.3390/ijms22147340 |
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author | Khamidullina, Alvina I. Varlamova, Ekaterina A. Hammoud, Nour Alhuda Yastrebova, Margarita A. Bruter, Alexandra V. |
author_facet | Khamidullina, Alvina I. Varlamova, Ekaterina A. Hammoud, Nour Alhuda Yastrebova, Margarita A. Bruter, Alexandra V. |
author_sort | Khamidullina, Alvina I. |
collection | PubMed |
description | Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials. |
format | Online Article Text |
id | pubmed-8304797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83047972021-07-25 Gene Transcription as a Therapeutic Target in Leukemia Khamidullina, Alvina I. Varlamova, Ekaterina A. Hammoud, Nour Alhuda Yastrebova, Margarita A. Bruter, Alexandra V. Int J Mol Sci Review Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials. MDPI 2021-07-08 /pmc/articles/PMC8304797/ /pubmed/34298959 http://dx.doi.org/10.3390/ijms22147340 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khamidullina, Alvina I. Varlamova, Ekaterina A. Hammoud, Nour Alhuda Yastrebova, Margarita A. Bruter, Alexandra V. Gene Transcription as a Therapeutic Target in Leukemia |
title | Gene Transcription as a Therapeutic Target in Leukemia |
title_full | Gene Transcription as a Therapeutic Target in Leukemia |
title_fullStr | Gene Transcription as a Therapeutic Target in Leukemia |
title_full_unstemmed | Gene Transcription as a Therapeutic Target in Leukemia |
title_short | Gene Transcription as a Therapeutic Target in Leukemia |
title_sort | gene transcription as a therapeutic target in leukemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304797/ https://www.ncbi.nlm.nih.gov/pubmed/34298959 http://dx.doi.org/10.3390/ijms22147340 |
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