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Gene Transcription as a Therapeutic Target in Leukemia

Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional mac...

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Detalles Bibliográficos
Autores principales: Khamidullina, Alvina I., Varlamova, Ekaterina A., Hammoud, Nour Alhuda, Yastrebova, Margarita A., Bruter, Alexandra V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304797/
https://www.ncbi.nlm.nih.gov/pubmed/34298959
http://dx.doi.org/10.3390/ijms22147340
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author Khamidullina, Alvina I.
Varlamova, Ekaterina A.
Hammoud, Nour Alhuda
Yastrebova, Margarita A.
Bruter, Alexandra V.
author_facet Khamidullina, Alvina I.
Varlamova, Ekaterina A.
Hammoud, Nour Alhuda
Yastrebova, Margarita A.
Bruter, Alexandra V.
author_sort Khamidullina, Alvina I.
collection PubMed
description Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials.
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spelling pubmed-83047972021-07-25 Gene Transcription as a Therapeutic Target in Leukemia Khamidullina, Alvina I. Varlamova, Ekaterina A. Hammoud, Nour Alhuda Yastrebova, Margarita A. Bruter, Alexandra V. Int J Mol Sci Review Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials. MDPI 2021-07-08 /pmc/articles/PMC8304797/ /pubmed/34298959 http://dx.doi.org/10.3390/ijms22147340 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khamidullina, Alvina I.
Varlamova, Ekaterina A.
Hammoud, Nour Alhuda
Yastrebova, Margarita A.
Bruter, Alexandra V.
Gene Transcription as a Therapeutic Target in Leukemia
title Gene Transcription as a Therapeutic Target in Leukemia
title_full Gene Transcription as a Therapeutic Target in Leukemia
title_fullStr Gene Transcription as a Therapeutic Target in Leukemia
title_full_unstemmed Gene Transcription as a Therapeutic Target in Leukemia
title_short Gene Transcription as a Therapeutic Target in Leukemia
title_sort gene transcription as a therapeutic target in leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304797/
https://www.ncbi.nlm.nih.gov/pubmed/34298959
http://dx.doi.org/10.3390/ijms22147340
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