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Fe65: A Scaffolding Protein of Actin Regulators

The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming com...

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Detalles Bibliográficos
Autores principales: Augustin, Vanessa, Kins, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304848/
https://www.ncbi.nlm.nih.gov/pubmed/34202290
http://dx.doi.org/10.3390/cells10071599
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author Augustin, Vanessa
Kins, Stefan
author_facet Augustin, Vanessa
Kins, Stefan
author_sort Augustin, Vanessa
collection PubMed
description The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signaling mechanisms of the APP-interacting protein Fe65 in the regulation of actin cytoskeleton dynamics in the context of various neuronal functions, such as cell migration, neurite outgrowth, and synaptic plasticity.
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spelling pubmed-83048482021-07-25 Fe65: A Scaffolding Protein of Actin Regulators Augustin, Vanessa Kins, Stefan Cells Review The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signaling mechanisms of the APP-interacting protein Fe65 in the regulation of actin cytoskeleton dynamics in the context of various neuronal functions, such as cell migration, neurite outgrowth, and synaptic plasticity. MDPI 2021-06-25 /pmc/articles/PMC8304848/ /pubmed/34202290 http://dx.doi.org/10.3390/cells10071599 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Augustin, Vanessa
Kins, Stefan
Fe65: A Scaffolding Protein of Actin Regulators
title Fe65: A Scaffolding Protein of Actin Regulators
title_full Fe65: A Scaffolding Protein of Actin Regulators
title_fullStr Fe65: A Scaffolding Protein of Actin Regulators
title_full_unstemmed Fe65: A Scaffolding Protein of Actin Regulators
title_short Fe65: A Scaffolding Protein of Actin Regulators
title_sort fe65: a scaffolding protein of actin regulators
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304848/
https://www.ncbi.nlm.nih.gov/pubmed/34202290
http://dx.doi.org/10.3390/cells10071599
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