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Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the...

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Autores principales: Isac, Raluca, Basaca, Diana-Georgiana, Olariu, Ioana-Cristina, Stroescu, Ramona F., Ardelean, Andrada-Mara, Steflea, Ruxandra M., Gafencu, Mihai, Chirita-Emandi, Adela, Bagiu, Iulia Cristina, Horhat, Florin George, Vulcanescu, Dan-Dumitru, Ionescu, Dan, Doros, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304885/
https://www.ncbi.nlm.nih.gov/pubmed/34356564
http://dx.doi.org/10.3390/children8070585
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author Isac, Raluca
Basaca, Diana-Georgiana
Olariu, Ioana-Cristina
Stroescu, Ramona F.
Ardelean, Andrada-Mara
Steflea, Ruxandra M.
Gafencu, Mihai
Chirita-Emandi, Adela
Bagiu, Iulia Cristina
Horhat, Florin George
Vulcanescu, Dan-Dumitru
Ionescu, Dan
Doros, Gabriela
author_facet Isac, Raluca
Basaca, Diana-Georgiana
Olariu, Ioana-Cristina
Stroescu, Ramona F.
Ardelean, Andrada-Mara
Steflea, Ruxandra M.
Gafencu, Mihai
Chirita-Emandi, Adela
Bagiu, Iulia Cristina
Horhat, Florin George
Vulcanescu, Dan-Dumitru
Ionescu, Dan
Doros, Gabriela
author_sort Isac, Raluca
collection PubMed
description Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the local trend in terms of bacterial uropathogen resistance in the western part of Romania in children with CAKUT and UTI. Methods: 252 children with CAKUT were admitted to our hospital over a five-year period. Of them, 91 developed at least one UTI episode, with a total number of 260 positive urine cultures. We collected data about age at diagnosis of CAKUT, sex, origin environment, type and side of CAKUT, number of UTIs, type of uropathogen, and uropathogens antibiotic resistance. Results: Distribution of uropathogens was Escherichia coli (38.84%), Klebsiella spp. (21.15%), Enterococcus spp. (15.76%), Proteus spp. (8.07%), Pseudomonas spp. (8.07%), Enterobacter spp. (2.3%), other Gram-negative bacteria (2.3%), and other Gram-positive bacteria (3.45%). High antibiotic resistance was detected for ampicillin, amoxicillin, and second-generation cephalosporins. Escherichia coli presented high resistance for cefepime and ceftriaxone. Pseudomonas spp. remained susceptible to amikacin, quinolones, and colistin. Vancomycin, teicoplanin, linezolid, and piperacillin/tazobactam remained effective in treating Gram-positive UTI. Conclusions: High antibiotic resistance was identified for frequently used antibiotics. Lower antibiotic resistance was observed for some broad-spectrum antibiotics. Understanding uropathogens’ antibiotic resistance is important in creating treatment recommendations, based on international guidelines, local resistance patterns, and patient particularities.
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spelling pubmed-83048852021-07-25 Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract Isac, Raluca Basaca, Diana-Georgiana Olariu, Ioana-Cristina Stroescu, Ramona F. Ardelean, Andrada-Mara Steflea, Ruxandra M. Gafencu, Mihai Chirita-Emandi, Adela Bagiu, Iulia Cristina Horhat, Florin George Vulcanescu, Dan-Dumitru Ionescu, Dan Doros, Gabriela Children (Basel) Article Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the local trend in terms of bacterial uropathogen resistance in the western part of Romania in children with CAKUT and UTI. Methods: 252 children with CAKUT were admitted to our hospital over a five-year period. Of them, 91 developed at least one UTI episode, with a total number of 260 positive urine cultures. We collected data about age at diagnosis of CAKUT, sex, origin environment, type and side of CAKUT, number of UTIs, type of uropathogen, and uropathogens antibiotic resistance. Results: Distribution of uropathogens was Escherichia coli (38.84%), Klebsiella spp. (21.15%), Enterococcus spp. (15.76%), Proteus spp. (8.07%), Pseudomonas spp. (8.07%), Enterobacter spp. (2.3%), other Gram-negative bacteria (2.3%), and other Gram-positive bacteria (3.45%). High antibiotic resistance was detected for ampicillin, amoxicillin, and second-generation cephalosporins. Escherichia coli presented high resistance for cefepime and ceftriaxone. Pseudomonas spp. remained susceptible to amikacin, quinolones, and colistin. Vancomycin, teicoplanin, linezolid, and piperacillin/tazobactam remained effective in treating Gram-positive UTI. Conclusions: High antibiotic resistance was identified for frequently used antibiotics. Lower antibiotic resistance was observed for some broad-spectrum antibiotics. Understanding uropathogens’ antibiotic resistance is important in creating treatment recommendations, based on international guidelines, local resistance patterns, and patient particularities. MDPI 2021-07-08 /pmc/articles/PMC8304885/ /pubmed/34356564 http://dx.doi.org/10.3390/children8070585 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Isac, Raluca
Basaca, Diana-Georgiana
Olariu, Ioana-Cristina
Stroescu, Ramona F.
Ardelean, Andrada-Mara
Steflea, Ruxandra M.
Gafencu, Mihai
Chirita-Emandi, Adela
Bagiu, Iulia Cristina
Horhat, Florin George
Vulcanescu, Dan-Dumitru
Ionescu, Dan
Doros, Gabriela
Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title_full Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title_fullStr Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title_full_unstemmed Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title_short Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract
title_sort antibiotic resistance patterns of uropathogens causing urinary tract infections in children with congenital anomalies of kidney and urinary tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304885/
https://www.ncbi.nlm.nih.gov/pubmed/34356564
http://dx.doi.org/10.3390/children8070585
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