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Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools
Background: No evidence has so far proven a significant role of schools in SARS-CoV-2 transmission, while the negative effects of their closure on children and adolescents are well documented. Surveillance, by means of frequent students and staff testing, has been advocated in order to implement sch...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304905/ https://www.ncbi.nlm.nih.gov/pubmed/34202882 http://dx.doi.org/10.3390/children8070544 |
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author | Carmagnola, Daniela Pellegrini, Gaia Canciani, Elena Henin, Dolaji Perrotta, Mariachiara Forlanini, Federica Barcellini, Lucia Dellavia, Claudia |
author_facet | Carmagnola, Daniela Pellegrini, Gaia Canciani, Elena Henin, Dolaji Perrotta, Mariachiara Forlanini, Federica Barcellini, Lucia Dellavia, Claudia |
author_sort | Carmagnola, Daniela |
collection | PubMed |
description | Background: No evidence has so far proven a significant role of schools in SARS-CoV-2 transmission, while the negative effects of their closure on children and adolescents are well documented. Surveillance, by means of frequent students and staff testing, has been advocated in order to implement school safety. Our aim was to report the results of a school surveillance program for the early detection of SARS-CoV-2 infection in pre- and asymptomatic subjects, by means of molecular salivary testing (MST). Methods: School surveillance in two schools in Milan, Italy, was carried out for six weeks. Each participant received a saliva collection kit, to be self-performed. Results: 401 students and 12 teachers were enrolled, and 5 positive children in 5 different classes were observed. All the cases were asymptomatic. Their nasopharyngeal swab was positive on the same day in four cases, while in one case it resulted negative on the same day and positive 3 days later. In one positive case, the whole family was set under surveillance. The positive child did not develop symptoms and no family member was infected. Conclusions: MST might represent an efficient way to actively survey communities in order to detect asymptomatic cases, thus limiting SARS-CoV-2 transmission. |
format | Online Article Text |
id | pubmed-8304905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83049052021-07-25 Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools Carmagnola, Daniela Pellegrini, Gaia Canciani, Elena Henin, Dolaji Perrotta, Mariachiara Forlanini, Federica Barcellini, Lucia Dellavia, Claudia Children (Basel) Article Background: No evidence has so far proven a significant role of schools in SARS-CoV-2 transmission, while the negative effects of their closure on children and adolescents are well documented. Surveillance, by means of frequent students and staff testing, has been advocated in order to implement school safety. Our aim was to report the results of a school surveillance program for the early detection of SARS-CoV-2 infection in pre- and asymptomatic subjects, by means of molecular salivary testing (MST). Methods: School surveillance in two schools in Milan, Italy, was carried out for six weeks. Each participant received a saliva collection kit, to be self-performed. Results: 401 students and 12 teachers were enrolled, and 5 positive children in 5 different classes were observed. All the cases were asymptomatic. Their nasopharyngeal swab was positive on the same day in four cases, while in one case it resulted negative on the same day and positive 3 days later. In one positive case, the whole family was set under surveillance. The positive child did not develop symptoms and no family member was infected. Conclusions: MST might represent an efficient way to actively survey communities in order to detect asymptomatic cases, thus limiting SARS-CoV-2 transmission. MDPI 2021-06-24 /pmc/articles/PMC8304905/ /pubmed/34202882 http://dx.doi.org/10.3390/children8070544 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carmagnola, Daniela Pellegrini, Gaia Canciani, Elena Henin, Dolaji Perrotta, Mariachiara Forlanini, Federica Barcellini, Lucia Dellavia, Claudia Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title | Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title_full | Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title_fullStr | Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title_full_unstemmed | Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title_short | Saliva Molecular Testing for SARS-CoV-2 Surveillance in Two Italian Primary Schools |
title_sort | saliva molecular testing for sars-cov-2 surveillance in two italian primary schools |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304905/ https://www.ncbi.nlm.nih.gov/pubmed/34202882 http://dx.doi.org/10.3390/children8070544 |
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