Cargando…
Trop2 Expression in Extramammary Paget’s Disease and Normal Skin
Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycopro...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304908/ https://www.ncbi.nlm.nih.gov/pubmed/34299325 http://dx.doi.org/10.3390/ijms22147706 |
_version_ | 1783727447679696896 |
---|---|
author | Ito, Takamichi Tanegashima, Keiko Tanaka, Yuka Hashimoto, Hiroki Murata, Maho Oda, Yoshinao Kaku-Ito, Yumiko |
author_facet | Ito, Takamichi Tanegashima, Keiko Tanaka, Yuka Hashimoto, Hiroki Murata, Maho Oda, Yoshinao Kaku-Ito, Yumiko |
author_sort | Ito, Takamichi |
collection | PubMed |
description | Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Sacituzumab govitecan, an antibody–drug conjugate of Trop2, has recently entered clinical use for the treatment of various solid cancers. However, little is known about the role of Trop2 in EMPD. In this study, we immunohistochemically examined Trop2 expression in 116 EMPD tissue samples and 10 normal skin tissues. In normal skin, Trop2 was expressed in the epidermal keratinocytes, inner root sheaths, and infundibulum/isthmus epithelium of hair follicles, eccrine/apocrine glands, and sebaceous glands. Most EMPD tissues exhibited homogeneous and strong Trop2 expression, and high Trop2 expression was significantly associated with worse disease-free survival (p = 0.0343). These results suggest the potential use of Trop2-targeted therapy for EMPD and improve our understanding of the skin-related adverse effects of current Trop2-targeted therapies such as sacituzumab govitecan. |
format | Online Article Text |
id | pubmed-8304908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83049082021-07-25 Trop2 Expression in Extramammary Paget’s Disease and Normal Skin Ito, Takamichi Tanegashima, Keiko Tanaka, Yuka Hashimoto, Hiroki Murata, Maho Oda, Yoshinao Kaku-Ito, Yumiko Int J Mol Sci Article Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Sacituzumab govitecan, an antibody–drug conjugate of Trop2, has recently entered clinical use for the treatment of various solid cancers. However, little is known about the role of Trop2 in EMPD. In this study, we immunohistochemically examined Trop2 expression in 116 EMPD tissue samples and 10 normal skin tissues. In normal skin, Trop2 was expressed in the epidermal keratinocytes, inner root sheaths, and infundibulum/isthmus epithelium of hair follicles, eccrine/apocrine glands, and sebaceous glands. Most EMPD tissues exhibited homogeneous and strong Trop2 expression, and high Trop2 expression was significantly associated with worse disease-free survival (p = 0.0343). These results suggest the potential use of Trop2-targeted therapy for EMPD and improve our understanding of the skin-related adverse effects of current Trop2-targeted therapies such as sacituzumab govitecan. MDPI 2021-07-19 /pmc/articles/PMC8304908/ /pubmed/34299325 http://dx.doi.org/10.3390/ijms22147706 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ito, Takamichi Tanegashima, Keiko Tanaka, Yuka Hashimoto, Hiroki Murata, Maho Oda, Yoshinao Kaku-Ito, Yumiko Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title | Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title_full | Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title_fullStr | Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title_full_unstemmed | Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title_short | Trop2 Expression in Extramammary Paget’s Disease and Normal Skin |
title_sort | trop2 expression in extramammary paget’s disease and normal skin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304908/ https://www.ncbi.nlm.nih.gov/pubmed/34299325 http://dx.doi.org/10.3390/ijms22147706 |
work_keys_str_mv | AT itotakamichi trop2expressioninextramammarypagetsdiseaseandnormalskin AT tanegashimakeiko trop2expressioninextramammarypagetsdiseaseandnormalskin AT tanakayuka trop2expressioninextramammarypagetsdiseaseandnormalskin AT hashimotohiroki trop2expressioninextramammarypagetsdiseaseandnormalskin AT muratamaho trop2expressioninextramammarypagetsdiseaseandnormalskin AT odayoshinao trop2expressioninextramammarypagetsdiseaseandnormalskin AT kakuitoyumiko trop2expressioninextramammarypagetsdiseaseandnormalskin |