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Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease

Background. Insulin resistance (IR) has been linked to inflammatory states. The aim of this study was to determine whether IR is increased in a cohort of inflammatory bowel disease (IBD) patients with low disease activity. We additionally intended to establish which factors were the determinants of...

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Autores principales: Carrillo-Palau, Marta, Hernández-Camba, Alejandro, Hernández Alvarez-Buylla, Noemi, Ramos, Laura, Alonso-Abreu, Inmaculada, Hernández-Pérez, Anjara, Vela, Milagros, Arranz, Laura, Hernández-Guerra, Manuel, González-Gay, Miguel Á., Ferraz-Amaro, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304915/
https://www.ncbi.nlm.nih.gov/pubmed/34300227
http://dx.doi.org/10.3390/jcm10143062
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author Carrillo-Palau, Marta
Hernández-Camba, Alejandro
Hernández Alvarez-Buylla, Noemi
Ramos, Laura
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Á.
Ferraz-Amaro, Iván
author_facet Carrillo-Palau, Marta
Hernández-Camba, Alejandro
Hernández Alvarez-Buylla, Noemi
Ramos, Laura
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Á.
Ferraz-Amaro, Iván
author_sort Carrillo-Palau, Marta
collection PubMed
description Background. Insulin resistance (IR) has been linked to inflammatory states. The aim of this study was to determine whether IR is increased in a cohort of inflammatory bowel disease (IBD) patients with low disease activity. We additionally intended to establish which factors were the determinants of IR in this population, including the presence of nonalcoholic fatty liver disease (NAFLD). Methods. Cross-sectional study encompassing 151 IBD patients and 174 non-diabetic controls. Insulin and C-peptide serum levels and IR and beta cell function (%B) indices based on homoeostatic model assessment (HOMA2) were assessed in patients and controls. Liver stiffness as measured by transient elastography, and the presence of NAFLD detected via ultrasound were additionally assessed. A multivariable regression analysis was performed to evaluate the differences in IR indexes between patients and controls, and to determine which predictor factors were associated with IR in IBD patients. Results. Neither HOMA2-IR (beta coef. −0.26 {95%CI −0.64–0.13}, p = 0.19) nor HOMA2-%B (beta coef. 15 {95%CI −14–44}, p = 0.31) indexes differed between patients and controls after fully multivariable analysis. Among classic IR risk factors, obesity, abdominal circumference, and triglycerides significantly and positively correlated with IR indexes in IBD patients. However, most features related to IBD, such as disease patterns, disease activity, and inflammatory markers, were not associated with IR. The presence of NAFLD was independently and significantly associated with beta cell dysfunction in patients with IBD (HOMA2—B grade 4, 251 ± 40 vs. grade 1, 107 ± 37, p = <0.001). Conclusions. IR is not increased in IBD patients with low disease activity compared to controls. However, the presence of NAFLD favors the development of IR in patients with IBD.
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spelling pubmed-83049152021-07-25 Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease Carrillo-Palau, Marta Hernández-Camba, Alejandro Hernández Alvarez-Buylla, Noemi Ramos, Laura Alonso-Abreu, Inmaculada Hernández-Pérez, Anjara Vela, Milagros Arranz, Laura Hernández-Guerra, Manuel González-Gay, Miguel Á. Ferraz-Amaro, Iván J Clin Med Article Background. Insulin resistance (IR) has been linked to inflammatory states. The aim of this study was to determine whether IR is increased in a cohort of inflammatory bowel disease (IBD) patients with low disease activity. We additionally intended to establish which factors were the determinants of IR in this population, including the presence of nonalcoholic fatty liver disease (NAFLD). Methods. Cross-sectional study encompassing 151 IBD patients and 174 non-diabetic controls. Insulin and C-peptide serum levels and IR and beta cell function (%B) indices based on homoeostatic model assessment (HOMA2) were assessed in patients and controls. Liver stiffness as measured by transient elastography, and the presence of NAFLD detected via ultrasound were additionally assessed. A multivariable regression analysis was performed to evaluate the differences in IR indexes between patients and controls, and to determine which predictor factors were associated with IR in IBD patients. Results. Neither HOMA2-IR (beta coef. −0.26 {95%CI −0.64–0.13}, p = 0.19) nor HOMA2-%B (beta coef. 15 {95%CI −14–44}, p = 0.31) indexes differed between patients and controls after fully multivariable analysis. Among classic IR risk factors, obesity, abdominal circumference, and triglycerides significantly and positively correlated with IR indexes in IBD patients. However, most features related to IBD, such as disease patterns, disease activity, and inflammatory markers, were not associated with IR. The presence of NAFLD was independently and significantly associated with beta cell dysfunction in patients with IBD (HOMA2—B grade 4, 251 ± 40 vs. grade 1, 107 ± 37, p = <0.001). Conclusions. IR is not increased in IBD patients with low disease activity compared to controls. However, the presence of NAFLD favors the development of IR in patients with IBD. MDPI 2021-07-10 /pmc/articles/PMC8304915/ /pubmed/34300227 http://dx.doi.org/10.3390/jcm10143062 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carrillo-Palau, Marta
Hernández-Camba, Alejandro
Hernández Alvarez-Buylla, Noemi
Ramos, Laura
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Á.
Ferraz-Amaro, Iván
Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title_full Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title_fullStr Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title_short Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
title_sort insulin resistance is not increased in inflammatory bowel disease patients but is related to non-alcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304915/
https://www.ncbi.nlm.nih.gov/pubmed/34300227
http://dx.doi.org/10.3390/jcm10143062
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