Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner

Oxygen supplementation is necessary to prevent mortality in severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that induces the retinopathy of prematurity. Here, w...

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Autores principales: Singh, Charandeep, Benos, Andrew, Grenell, Allison, Rao, Sujata, Anand-Apte, Bela, Sears, Jonathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304924/
https://www.ncbi.nlm.nih.gov/pubmed/34202240
http://dx.doi.org/10.3390/life11070614
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author Singh, Charandeep
Benos, Andrew
Grenell, Allison
Rao, Sujata
Anand-Apte, Bela
Sears, Jonathan E.
author_facet Singh, Charandeep
Benos, Andrew
Grenell, Allison
Rao, Sujata
Anand-Apte, Bela
Sears, Jonathan E.
author_sort Singh, Charandeep
collection PubMed
description Oxygen supplementation is necessary to prevent mortality in severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that induces the retinopathy of prematurity. Here, we report that hyperoxia regulates the cell cycle and retinal endothelial cell proliferation in a previously unknown Myc-dependent manner, which contributes to oxygen-induced retinopathy.
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spelling pubmed-83049242021-07-25 Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner Singh, Charandeep Benos, Andrew Grenell, Allison Rao, Sujata Anand-Apte, Bela Sears, Jonathan E. Life (Basel) Brief Report Oxygen supplementation is necessary to prevent mortality in severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that induces the retinopathy of prematurity. Here, we report that hyperoxia regulates the cell cycle and retinal endothelial cell proliferation in a previously unknown Myc-dependent manner, which contributes to oxygen-induced retinopathy. MDPI 2021-06-25 /pmc/articles/PMC8304924/ /pubmed/34202240 http://dx.doi.org/10.3390/life11070614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Singh, Charandeep
Benos, Andrew
Grenell, Allison
Rao, Sujata
Anand-Apte, Bela
Sears, Jonathan E.
Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title_full Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title_fullStr Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title_full_unstemmed Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title_short Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
title_sort hyperoxia inhibits proliferation of retinal endothelial cells in a myc-dependent manner
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304924/
https://www.ncbi.nlm.nih.gov/pubmed/34202240
http://dx.doi.org/10.3390/life11070614
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AT raosujata hyperoxiainhibitsproliferationofretinalendothelialcellsinamycdependentmanner
AT anandaptebela hyperoxiainhibitsproliferationofretinalendothelialcellsinamycdependentmanner
AT searsjonathane hyperoxiainhibitsproliferationofretinalendothelialcellsinamycdependentmanner

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