Cargando…
A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed f...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304948/ https://www.ncbi.nlm.nih.gov/pubmed/34359399 http://dx.doi.org/10.3390/foods10071529 |
_version_ | 1783727457175601152 |
---|---|
author | Roila, Rossana Branciari, Raffaella Verdini, Emanuela Ranucci, David Valiani, Andrea Pelliccia, Alessandro Fioroni, Laura Pecorelli, Ivan |
author_facet | Roila, Rossana Branciari, Raffaella Verdini, Emanuela Ranucci, David Valiani, Andrea Pelliccia, Alessandro Fioroni, Laura Pecorelli, Ivan |
author_sort | Roila, Rossana |
collection | PubMed |
description | Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed for all age populations of central Italy with regard to milk and cheese consumption by means of the margin of exposure (MOE). In total, 16,934 cow and ewe’s milk samples were collected from 2014 to 2020 and analyzed by an enzyme-linked immunosorbent assay (ELISA) screening method, confirmed by high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The average concentration of AFM1 in cow’s milk ranged from 0.009 to 0.015 µg/kg, while in ewe’s milk, the average concentration ranged from 0.009 to 0.013 µg/kg. The average amount of AFM1 exposure ranged from 0.00005 to 0.00195 g/kg bw/day, with the main contributor represented by drinking milk, followed by the consumption of soft cheeses. A high level of public health concern related to the youngest consumers has arisen from risk characterizations highlighting the need for constant monitoring of AFM1′s occurrence in milk by inspection authorities, alongside regular updates with regard to exposure assessments. |
format | Online Article Text |
id | pubmed-8304948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83049482021-07-25 A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy Roila, Rossana Branciari, Raffaella Verdini, Emanuela Ranucci, David Valiani, Andrea Pelliccia, Alessandro Fioroni, Laura Pecorelli, Ivan Foods Article Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed for all age populations of central Italy with regard to milk and cheese consumption by means of the margin of exposure (MOE). In total, 16,934 cow and ewe’s milk samples were collected from 2014 to 2020 and analyzed by an enzyme-linked immunosorbent assay (ELISA) screening method, confirmed by high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The average concentration of AFM1 in cow’s milk ranged from 0.009 to 0.015 µg/kg, while in ewe’s milk, the average concentration ranged from 0.009 to 0.013 µg/kg. The average amount of AFM1 exposure ranged from 0.00005 to 0.00195 g/kg bw/day, with the main contributor represented by drinking milk, followed by the consumption of soft cheeses. A high level of public health concern related to the youngest consumers has arisen from risk characterizations highlighting the need for constant monitoring of AFM1′s occurrence in milk by inspection authorities, alongside regular updates with regard to exposure assessments. MDPI 2021-07-02 /pmc/articles/PMC8304948/ /pubmed/34359399 http://dx.doi.org/10.3390/foods10071529 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Roila, Rossana Branciari, Raffaella Verdini, Emanuela Ranucci, David Valiani, Andrea Pelliccia, Alessandro Fioroni, Laura Pecorelli, Ivan A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title | A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title_full | A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title_fullStr | A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title_full_unstemmed | A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title_short | A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy |
title_sort | study of the occurrence of aflatoxin m1 in milk supply chain over a seven-year period (2014–2020): human exposure assessment and risk characterization in the population of central italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304948/ https://www.ncbi.nlm.nih.gov/pubmed/34359399 http://dx.doi.org/10.3390/foods10071529 |
work_keys_str_mv | AT roilarossana astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT branciariraffaella astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT verdiniemanuela astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT ranuccidavid astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT valianiandrea astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT pellicciaalessandro astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT fioronilaura astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT pecorelliivan astudyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT roilarossana studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT branciariraffaella studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT verdiniemanuela studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT ranuccidavid studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT valianiandrea studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT pellicciaalessandro studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT fioronilaura studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly AT pecorelliivan studyoftheoccurrenceofaflatoxinm1inmilksupplychainoverasevenyearperiod20142020humanexposureassessmentandriskcharacterizationinthepopulationofcentralitaly |