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A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy

Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed f...

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Autores principales: Roila, Rossana, Branciari, Raffaella, Verdini, Emanuela, Ranucci, David, Valiani, Andrea, Pelliccia, Alessandro, Fioroni, Laura, Pecorelli, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304948/
https://www.ncbi.nlm.nih.gov/pubmed/34359399
http://dx.doi.org/10.3390/foods10071529
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author Roila, Rossana
Branciari, Raffaella
Verdini, Emanuela
Ranucci, David
Valiani, Andrea
Pelliccia, Alessandro
Fioroni, Laura
Pecorelli, Ivan
author_facet Roila, Rossana
Branciari, Raffaella
Verdini, Emanuela
Ranucci, David
Valiani, Andrea
Pelliccia, Alessandro
Fioroni, Laura
Pecorelli, Ivan
author_sort Roila, Rossana
collection PubMed
description Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed for all age populations of central Italy with regard to milk and cheese consumption by means of the margin of exposure (MOE). In total, 16,934 cow and ewe’s milk samples were collected from 2014 to 2020 and analyzed by an enzyme-linked immunosorbent assay (ELISA) screening method, confirmed by high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The average concentration of AFM1 in cow’s milk ranged from 0.009 to 0.015 µg/kg, while in ewe’s milk, the average concentration ranged from 0.009 to 0.013 µg/kg. The average amount of AFM1 exposure ranged from 0.00005 to 0.00195 g/kg bw/day, with the main contributor represented by drinking milk, followed by the consumption of soft cheeses. A high level of public health concern related to the youngest consumers has arisen from risk characterizations highlighting the need for constant monitoring of AFM1′s occurrence in milk by inspection authorities, alongside regular updates with regard to exposure assessments.
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spelling pubmed-83049482021-07-25 A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy Roila, Rossana Branciari, Raffaella Verdini, Emanuela Ranucci, David Valiani, Andrea Pelliccia, Alessandro Fioroni, Laura Pecorelli, Ivan Foods Article Aflatoxin food contamination represents a rising global issue that will continue to increase due to climate change. Aflatoxin M1 (AFM1) is of high concern for the whole dairy industry. In light of AFM1′s harmful potential, a human health exposure assessment and risk characterization were performed for all age populations of central Italy with regard to milk and cheese consumption by means of the margin of exposure (MOE). In total, 16,934 cow and ewe’s milk samples were collected from 2014 to 2020 and analyzed by an enzyme-linked immunosorbent assay (ELISA) screening method, confirmed by high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The average concentration of AFM1 in cow’s milk ranged from 0.009 to 0.015 µg/kg, while in ewe’s milk, the average concentration ranged from 0.009 to 0.013 µg/kg. The average amount of AFM1 exposure ranged from 0.00005 to 0.00195 g/kg bw/day, with the main contributor represented by drinking milk, followed by the consumption of soft cheeses. A high level of public health concern related to the youngest consumers has arisen from risk characterizations highlighting the need for constant monitoring of AFM1′s occurrence in milk by inspection authorities, alongside regular updates with regard to exposure assessments. MDPI 2021-07-02 /pmc/articles/PMC8304948/ /pubmed/34359399 http://dx.doi.org/10.3390/foods10071529 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Roila, Rossana
Branciari, Raffaella
Verdini, Emanuela
Ranucci, David
Valiani, Andrea
Pelliccia, Alessandro
Fioroni, Laura
Pecorelli, Ivan
A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title_full A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title_fullStr A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title_full_unstemmed A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title_short A Study of the Occurrence of Aflatoxin M1 in Milk Supply Chain over a Seven-Year Period (2014–2020): Human Exposure Assessment and Risk Characterization in the Population of Central Italy
title_sort study of the occurrence of aflatoxin m1 in milk supply chain over a seven-year period (2014–2020): human exposure assessment and risk characterization in the population of central italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304948/
https://www.ncbi.nlm.nih.gov/pubmed/34359399
http://dx.doi.org/10.3390/foods10071529
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