Endoscopy to Diagnose and Prevent Digestive Cancers in Lynch Syndrome

SIMPLE SUMMARY: Lynch syndrome is characterized by a higher relative risk of developing certain cancers, especially digestive cancers. Many guidelines from different scientific societies are now available and allow excellent follow-up for these patients, but occasionally propose divergent management approaches. We provide here a synthesis of these guidelines and a focus on prevention, diagnosis, and endoscopic follow-up of these digestive cancers and early neoplasia. ABSTRACT: Lynch syndrome patients could benefit from various recommendations to prevent digestive cancers. In this review, we summarize the criteria to identify Lynch syndrome in patients with digestive cancers. We detail endoscopic screening procedures in patients with Lynch syndrome for gastric, small bowel, pancreatic, and colorectal cancers. We review the precise modalities of endoscopic follow-up, particularly the discrepancies that exist between the guidelines of the various scientific societies. We discuss the treatment of colorectal cancers in Lynch syndrome cases and patient adherence to endoscopic follow-up programs.