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Mercury Toxicity and Neurogenesis in the Mammalian Brain
The mammalian brain is formed from billions of cells that include a wide array of neuronal and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during embryonic, fetal, and early postnatal developmental periods. The process of embryonic neurogenesis includes prol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305137/ https://www.ncbi.nlm.nih.gov/pubmed/34299140 http://dx.doi.org/10.3390/ijms22147520 |
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author | Abbott, Louise C. Nigussie, Fikru |
author_facet | Abbott, Louise C. Nigussie, Fikru |
author_sort | Abbott, Louise C. |
collection | PubMed |
description | The mammalian brain is formed from billions of cells that include a wide array of neuronal and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during embryonic, fetal, and early postnatal developmental periods. The process of embryonic neurogenesis includes proliferation, differentiation, migration, the programmed death of some newly formed cells, and the final integration of differentiated neurons into neural networks. Adult neurogenesis also occurs in the mammalian brain, but adult neurogenesis is beyond the scope of this review. Developing embryonic neurons are particularly susceptible to neurotoxicants and especially mercury toxicity. This review focused on observations concerning how mercury, and in particular, methylmercury, affects neurogenesis in the developing mammalian brain. We summarized information on models used to study developmental mercury toxicity, theories of pathogenesis, and treatments that could be used to reduce the toxic effects of mercury on developing neurons. |
format | Online Article Text |
id | pubmed-8305137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83051372021-07-25 Mercury Toxicity and Neurogenesis in the Mammalian Brain Abbott, Louise C. Nigussie, Fikru Int J Mol Sci Review The mammalian brain is formed from billions of cells that include a wide array of neuronal and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during embryonic, fetal, and early postnatal developmental periods. The process of embryonic neurogenesis includes proliferation, differentiation, migration, the programmed death of some newly formed cells, and the final integration of differentiated neurons into neural networks. Adult neurogenesis also occurs in the mammalian brain, but adult neurogenesis is beyond the scope of this review. Developing embryonic neurons are particularly susceptible to neurotoxicants and especially mercury toxicity. This review focused on observations concerning how mercury, and in particular, methylmercury, affects neurogenesis in the developing mammalian brain. We summarized information on models used to study developmental mercury toxicity, theories of pathogenesis, and treatments that could be used to reduce the toxic effects of mercury on developing neurons. MDPI 2021-07-14 /pmc/articles/PMC8305137/ /pubmed/34299140 http://dx.doi.org/10.3390/ijms22147520 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Abbott, Louise C. Nigussie, Fikru Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title | Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title_full | Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title_fullStr | Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title_full_unstemmed | Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title_short | Mercury Toxicity and Neurogenesis in the Mammalian Brain |
title_sort | mercury toxicity and neurogenesis in the mammalian brain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305137/ https://www.ncbi.nlm.nih.gov/pubmed/34299140 http://dx.doi.org/10.3390/ijms22147520 |
work_keys_str_mv | AT abbottlouisec mercurytoxicityandneurogenesisinthemammalianbrain AT nigussiefikru mercurytoxicityandneurogenesisinthemammalianbrain |