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Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues

Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose ti...

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Detalles Bibliográficos
Autores principales: Dilworth, Lowell, Facey, Aldeam, Omoruyi, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305176/
https://www.ncbi.nlm.nih.gov/pubmed/34299261
http://dx.doi.org/10.3390/ijms22147644
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author Dilworth, Lowell
Facey, Aldeam
Omoruyi, Felix
author_facet Dilworth, Lowell
Facey, Aldeam
Omoruyi, Felix
author_sort Dilworth, Lowell
collection PubMed
description Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease.
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spelling pubmed-83051762021-07-25 Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues Dilworth, Lowell Facey, Aldeam Omoruyi, Felix Int J Mol Sci Review Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease. MDPI 2021-07-16 /pmc/articles/PMC8305176/ /pubmed/34299261 http://dx.doi.org/10.3390/ijms22147644 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dilworth, Lowell
Facey, Aldeam
Omoruyi, Felix
Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title_full Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title_fullStr Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title_full_unstemmed Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title_short Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
title_sort diabetes mellitus and its metabolic complications: the role of adipose tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305176/
https://www.ncbi.nlm.nih.gov/pubmed/34299261
http://dx.doi.org/10.3390/ijms22147644
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