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Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose ti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305176/ https://www.ncbi.nlm.nih.gov/pubmed/34299261 http://dx.doi.org/10.3390/ijms22147644 |
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author | Dilworth, Lowell Facey, Aldeam Omoruyi, Felix |
author_facet | Dilworth, Lowell Facey, Aldeam Omoruyi, Felix |
author_sort | Dilworth, Lowell |
collection | PubMed |
description | Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease. |
format | Online Article Text |
id | pubmed-8305176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83051762021-07-25 Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues Dilworth, Lowell Facey, Aldeam Omoruyi, Felix Int J Mol Sci Review Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease. MDPI 2021-07-16 /pmc/articles/PMC8305176/ /pubmed/34299261 http://dx.doi.org/10.3390/ijms22147644 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dilworth, Lowell Facey, Aldeam Omoruyi, Felix Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title_full | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title_fullStr | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title_full_unstemmed | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title_short | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
title_sort | diabetes mellitus and its metabolic complications: the role of adipose tissues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305176/ https://www.ncbi.nlm.nih.gov/pubmed/34299261 http://dx.doi.org/10.3390/ijms22147644 |
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