Effects of Statins on Renin–Angiotensin System

Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progre...

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Detalles Bibliográficos
Autores principales: Kiaie, Nasim, Gorabi, Armita Mahdavi, Reiner, Željko, Jamialahmadi, Tannaz, Ruscica, Massimiliano, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305238/
https://www.ncbi.nlm.nih.gov/pubmed/34357323
http://dx.doi.org/10.3390/jcdd8070080
Descripción
Sumario:Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.

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