Cargando…

An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach

The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activiti...

Descripción completa

Detalles Bibliográficos
Autores principales: Berta, Giovanni Nicolao, Romano, Federica, Vallone, Roberta, Abbadessa, Giuliana, Di Scipio, Federica, Defabianis, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305301/
https://www.ncbi.nlm.nih.gov/pubmed/34300720
http://dx.doi.org/10.3390/ma14143801
_version_ 1783727541721235456
author Berta, Giovanni Nicolao
Romano, Federica
Vallone, Roberta
Abbadessa, Giuliana
Di Scipio, Federica
Defabianis, Patrizia
author_facet Berta, Giovanni Nicolao
Romano, Federica
Vallone, Roberta
Abbadessa, Giuliana
Di Scipio, Federica
Defabianis, Patrizia
author_sort Berta, Giovanni Nicolao
collection PubMed
description The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activities, was included in a nanovector of 2-hydroxypropyl-beta-cyclodextrins (HPβCD) to improve its bioavailability. A total of 64 children between two and five years of age with plaque-induced gingivitis were randomly included in two equal groups. Both groups were enrolled in a mechanical plaque control program for a period of four weeks, while the test group was also instructed to use the RV-HPβCD mouthwash (in spray formulation) once daily, after toothbrushing. All children underwent three oral hygiene motivation sessions, 14 days apart, during which the full-mouth presence of bacterial plaque, gingival inflammation, dental stain and salivary pH were recorded. At two-week appointment, they also received professional plaque removal. The use of RV-based oral spray significantly reduced the amount of dental plaque and the percentage of bleeding sites and improved salivary pH compared to the control group at both two- and four-week examinations. Based on these promising results, the local delivery of RV-HPβCD via oral spray could enhance the control of dental biofilm in early childhood, when antiseptic mouthwashes are not recommended.
format Online
Article
Text
id pubmed-8305301
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83053012021-07-25 An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach Berta, Giovanni Nicolao Romano, Federica Vallone, Roberta Abbadessa, Giuliana Di Scipio, Federica Defabianis, Patrizia Materials (Basel) Article The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activities, was included in a nanovector of 2-hydroxypropyl-beta-cyclodextrins (HPβCD) to improve its bioavailability. A total of 64 children between two and five years of age with plaque-induced gingivitis were randomly included in two equal groups. Both groups were enrolled in a mechanical plaque control program for a period of four weeks, while the test group was also instructed to use the RV-HPβCD mouthwash (in spray formulation) once daily, after toothbrushing. All children underwent three oral hygiene motivation sessions, 14 days apart, during which the full-mouth presence of bacterial plaque, gingival inflammation, dental stain and salivary pH were recorded. At two-week appointment, they also received professional plaque removal. The use of RV-based oral spray significantly reduced the amount of dental plaque and the percentage of bleeding sites and improved salivary pH compared to the control group at both two- and four-week examinations. Based on these promising results, the local delivery of RV-HPβCD via oral spray could enhance the control of dental biofilm in early childhood, when antiseptic mouthwashes are not recommended. MDPI 2021-07-07 /pmc/articles/PMC8305301/ /pubmed/34300720 http://dx.doi.org/10.3390/ma14143801 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Berta, Giovanni Nicolao
Romano, Federica
Vallone, Roberta
Abbadessa, Giuliana
Di Scipio, Federica
Defabianis, Patrizia
An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title_full An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title_fullStr An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title_full_unstemmed An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title_short An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
title_sort innovative strategy for oral biofilm control in early childhood based on a resveratrol-cyclodextrin nanotechnology approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305301/
https://www.ncbi.nlm.nih.gov/pubmed/34300720
http://dx.doi.org/10.3390/ma14143801
work_keys_str_mv AT bertagiovanninicolao aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT romanofederica aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT valloneroberta aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT abbadessagiuliana aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT discipiofederica aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT defabianispatrizia aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT bertagiovanninicolao innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT romanofederica innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT valloneroberta innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT abbadessagiuliana innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT discipiofederica innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach
AT defabianispatrizia innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach