Cargando…
An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach
The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activiti...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305301/ https://www.ncbi.nlm.nih.gov/pubmed/34300720 http://dx.doi.org/10.3390/ma14143801 |
_version_ | 1783727541721235456 |
---|---|
author | Berta, Giovanni Nicolao Romano, Federica Vallone, Roberta Abbadessa, Giuliana Di Scipio, Federica Defabianis, Patrizia |
author_facet | Berta, Giovanni Nicolao Romano, Federica Vallone, Roberta Abbadessa, Giuliana Di Scipio, Federica Defabianis, Patrizia |
author_sort | Berta, Giovanni Nicolao |
collection | PubMed |
description | The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activities, was included in a nanovector of 2-hydroxypropyl-beta-cyclodextrins (HPβCD) to improve its bioavailability. A total of 64 children between two and five years of age with plaque-induced gingivitis were randomly included in two equal groups. Both groups were enrolled in a mechanical plaque control program for a period of four weeks, while the test group was also instructed to use the RV-HPβCD mouthwash (in spray formulation) once daily, after toothbrushing. All children underwent three oral hygiene motivation sessions, 14 days apart, during which the full-mouth presence of bacterial plaque, gingival inflammation, dental stain and salivary pH were recorded. At two-week appointment, they also received professional plaque removal. The use of RV-based oral spray significantly reduced the amount of dental plaque and the percentage of bleeding sites and improved salivary pH compared to the control group at both two- and four-week examinations. Based on these promising results, the local delivery of RV-HPβCD via oral spray could enhance the control of dental biofilm in early childhood, when antiseptic mouthwashes are not recommended. |
format | Online Article Text |
id | pubmed-8305301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83053012021-07-25 An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach Berta, Giovanni Nicolao Romano, Federica Vallone, Roberta Abbadessa, Giuliana Di Scipio, Federica Defabianis, Patrizia Materials (Basel) Article The purpose of this randomized controlled study was to evaluate the clinical efficacy of a novel oral spray containing resveratrol (RV) in controlling bacterial biofilm and gingival inflammation in early childhood. RV, a natural polyphenol, known for its anti-inflammatory and anti-infective activities, was included in a nanovector of 2-hydroxypropyl-beta-cyclodextrins (HPβCD) to improve its bioavailability. A total of 64 children between two and five years of age with plaque-induced gingivitis were randomly included in two equal groups. Both groups were enrolled in a mechanical plaque control program for a period of four weeks, while the test group was also instructed to use the RV-HPβCD mouthwash (in spray formulation) once daily, after toothbrushing. All children underwent three oral hygiene motivation sessions, 14 days apart, during which the full-mouth presence of bacterial plaque, gingival inflammation, dental stain and salivary pH were recorded. At two-week appointment, they also received professional plaque removal. The use of RV-based oral spray significantly reduced the amount of dental plaque and the percentage of bleeding sites and improved salivary pH compared to the control group at both two- and four-week examinations. Based on these promising results, the local delivery of RV-HPβCD via oral spray could enhance the control of dental biofilm in early childhood, when antiseptic mouthwashes are not recommended. MDPI 2021-07-07 /pmc/articles/PMC8305301/ /pubmed/34300720 http://dx.doi.org/10.3390/ma14143801 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Berta, Giovanni Nicolao Romano, Federica Vallone, Roberta Abbadessa, Giuliana Di Scipio, Federica Defabianis, Patrizia An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title | An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title_full | An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title_fullStr | An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title_full_unstemmed | An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title_short | An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach |
title_sort | innovative strategy for oral biofilm control in early childhood based on a resveratrol-cyclodextrin nanotechnology approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305301/ https://www.ncbi.nlm.nih.gov/pubmed/34300720 http://dx.doi.org/10.3390/ma14143801 |
work_keys_str_mv | AT bertagiovanninicolao aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT romanofederica aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT valloneroberta aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT abbadessagiuliana aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT discipiofederica aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT defabianispatrizia aninnovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT bertagiovanninicolao innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT romanofederica innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT valloneroberta innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT abbadessagiuliana innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT discipiofederica innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach AT defabianispatrizia innovativestrategyfororalbiofilmcontrolinearlychildhoodbasedonaresveratrolcyclodextrinnanotechnologyapproach |