Cargando…

DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Śnit, Mirosław, Misiołek, Maciej, Ścierski, Wojciech, Koniewska, Anna, Stryjewska-Makuch, Grażyna, Okła, Sławomir, Grzeszczak, Władysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305316/
https://www.ncbi.nlm.nih.gov/pubmed/34299935
http://dx.doi.org/10.3390/ijerph18147486
_version_ 1783727545487720448
author Śnit, Mirosław
Misiołek, Maciej
Ścierski, Wojciech
Koniewska, Anna
Stryjewska-Makuch, Grażyna
Okła, Sławomir
Grzeszczak, Władysław
author_facet Śnit, Mirosław
Misiołek, Maciej
Ścierski, Wojciech
Koniewska, Anna
Stryjewska-Makuch, Grażyna
Okła, Sławomir
Grzeszczak, Władysław
author_sort Śnit, Mirosław
collection PubMed
description AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.
format Online
Article
Text
id pubmed-8305316
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83053162021-07-25 DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk Śnit, Mirosław Misiołek, Maciej Ścierski, Wojciech Koniewska, Anna Stryjewska-Makuch, Grażyna Okła, Sławomir Grzeszczak, Władysław Int J Environ Res Public Health Article AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer. MDPI 2021-07-13 /pmc/articles/PMC8305316/ /pubmed/34299935 http://dx.doi.org/10.3390/ijerph18147486 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Śnit, Mirosław
Misiołek, Maciej
Ścierski, Wojciech
Koniewska, Anna
Stryjewska-Makuch, Grażyna
Okła, Sławomir
Grzeszczak, Władysław
DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title_full DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title_fullStr DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title_full_unstemmed DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title_short DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
title_sort diaph2, ptprd and hic1 gene polymorphisms and laryngeal cancer risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305316/
https://www.ncbi.nlm.nih.gov/pubmed/34299935
http://dx.doi.org/10.3390/ijerph18147486
work_keys_str_mv AT snitmirosław diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT misiołekmaciej diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT scierskiwojciech diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT koniewskaanna diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT stryjewskamakuchgrazyna diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT okłasławomir diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk
AT grzeszczakwładysław diaph2ptprdandhic1genepolymorphismsandlaryngealcancerrisk