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DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305316/ https://www.ncbi.nlm.nih.gov/pubmed/34299935 http://dx.doi.org/10.3390/ijerph18147486 |
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author | Śnit, Mirosław Misiołek, Maciej Ścierski, Wojciech Koniewska, Anna Stryjewska-Makuch, Grażyna Okła, Sławomir Grzeszczak, Władysław |
author_facet | Śnit, Mirosław Misiołek, Maciej Ścierski, Wojciech Koniewska, Anna Stryjewska-Makuch, Grażyna Okła, Sławomir Grzeszczak, Władysław |
author_sort | Śnit, Mirosław |
collection | PubMed |
description | AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer. |
format | Online Article Text |
id | pubmed-8305316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83053162021-07-25 DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk Śnit, Mirosław Misiołek, Maciej Ścierski, Wojciech Koniewska, Anna Stryjewska-Makuch, Grażyna Okła, Sławomir Grzeszczak, Władysław Int J Environ Res Public Health Article AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer. MDPI 2021-07-13 /pmc/articles/PMC8305316/ /pubmed/34299935 http://dx.doi.org/10.3390/ijerph18147486 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Śnit, Mirosław Misiołek, Maciej Ścierski, Wojciech Koniewska, Anna Stryjewska-Makuch, Grażyna Okła, Sławomir Grzeszczak, Władysław DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title_full | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title_fullStr | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title_full_unstemmed | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title_short | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk |
title_sort | diaph2, ptprd and hic1 gene polymorphisms and laryngeal cancer risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305316/ https://www.ncbi.nlm.nih.gov/pubmed/34299935 http://dx.doi.org/10.3390/ijerph18147486 |
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