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Switching TNFα inhibitors: Patterns and determinants
The aim of this study was to assess switching patterns and determinants for switching in patients initiating TNFα inhibitor (TNFα‐i) treatment. Patients were included who started TNFα‐i treatment between July 1, 2012 and December 31, 2017, from three Dutch hospitals, and were diagnosed with rheumati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305431/ https://www.ncbi.nlm.nih.gov/pubmed/34302442 http://dx.doi.org/10.1002/prp2.843 |
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author | Meijboom, Rosanne W. Gardarsdottir, Helga Becker, Matthijs L. de Groot, Mark C. H. Movig, Kris L. L. Kuijvenhoven, Johan Egberts, Toine C. G. Leufkens, Hubert G. M. Giezen, Thijs J. |
author_facet | Meijboom, Rosanne W. Gardarsdottir, Helga Becker, Matthijs L. de Groot, Mark C. H. Movig, Kris L. L. Kuijvenhoven, Johan Egberts, Toine C. G. Leufkens, Hubert G. M. Giezen, Thijs J. |
author_sort | Meijboom, Rosanne W. |
collection | PubMed |
description | The aim of this study was to assess switching patterns and determinants for switching in patients initiating TNFα inhibitor (TNFα‐i) treatment. Patients were included who started TNFα‐i treatment between July 1, 2012 and December 31, 2017, from three Dutch hospitals, and were diagnosed with rheumatic diseases (RD), inflammatory bowel disease (IBD), or psoriasis. Outcomes were switching, defined as initiating another biological; switching patterns including multiple switches until the end of follow‐up; determinants for first switch, assessed using multivariate logistic regression. A total of 2228 patients were included (median age 43.3 years, 57% female), of which 52% (n = 1155) received TNFα‐i for RD, 43% (n = 967) for IBD, and 5% (n = 106) for psoriasis. About 16.6% of RD patients, 14.5% of IBD patients, and 16.0% of psoriasis patients switched at least once, mainly to another TNFα‐i. TNFα‐i dose escalation (OR 13.78, 95% CI 1.40–135.0) and high‐dose corticosteroids initiation (OR 3.62, 95% CI 1.10–12.15) were determinants for switching in RD patients. TNFα‐i dose escalation (OR 8.22, 95% CI 3.76–17.93), immunomodulator initiation/dose escalation (OR 2.13, 95% CI 1.04–4.34), high‐dose corticosteroids initiation (OR 6.91, 95% CI 2.81–17.01) and serum concentration measurement (OR 5.44, 95% CI 2.74–10.79) were determinants for switching in IBD patients. Switching biological treatment occurred in about one in six patients. RD patients with TNFα‐i dose escalation and/or high‐dose corticosteroids initiation were more likely to switch. IBD patients with TNFα‐i or immunomodulator initiation/dose escalation, high‐dose corticosteroids initiation or serum concentration measurement were more likely to switch. These findings might help clinicians anticipating switching in TNFα‐i treatment. |
format | Online Article Text |
id | pubmed-8305431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83054312021-07-28 Switching TNFα inhibitors: Patterns and determinants Meijboom, Rosanne W. Gardarsdottir, Helga Becker, Matthijs L. de Groot, Mark C. H. Movig, Kris L. L. Kuijvenhoven, Johan Egberts, Toine C. G. Leufkens, Hubert G. M. Giezen, Thijs J. Pharmacol Res Perspect Original Articles The aim of this study was to assess switching patterns and determinants for switching in patients initiating TNFα inhibitor (TNFα‐i) treatment. Patients were included who started TNFα‐i treatment between July 1, 2012 and December 31, 2017, from three Dutch hospitals, and were diagnosed with rheumatic diseases (RD), inflammatory bowel disease (IBD), or psoriasis. Outcomes were switching, defined as initiating another biological; switching patterns including multiple switches until the end of follow‐up; determinants for first switch, assessed using multivariate logistic regression. A total of 2228 patients were included (median age 43.3 years, 57% female), of which 52% (n = 1155) received TNFα‐i for RD, 43% (n = 967) for IBD, and 5% (n = 106) for psoriasis. About 16.6% of RD patients, 14.5% of IBD patients, and 16.0% of psoriasis patients switched at least once, mainly to another TNFα‐i. TNFα‐i dose escalation (OR 13.78, 95% CI 1.40–135.0) and high‐dose corticosteroids initiation (OR 3.62, 95% CI 1.10–12.15) were determinants for switching in RD patients. TNFα‐i dose escalation (OR 8.22, 95% CI 3.76–17.93), immunomodulator initiation/dose escalation (OR 2.13, 95% CI 1.04–4.34), high‐dose corticosteroids initiation (OR 6.91, 95% CI 2.81–17.01) and serum concentration measurement (OR 5.44, 95% CI 2.74–10.79) were determinants for switching in IBD patients. Switching biological treatment occurred in about one in six patients. RD patients with TNFα‐i dose escalation and/or high‐dose corticosteroids initiation were more likely to switch. IBD patients with TNFα‐i or immunomodulator initiation/dose escalation, high‐dose corticosteroids initiation or serum concentration measurement were more likely to switch. These findings might help clinicians anticipating switching in TNFα‐i treatment. John Wiley and Sons Inc. 2021-07-24 /pmc/articles/PMC8305431/ /pubmed/34302442 http://dx.doi.org/10.1002/prp2.843 Text en © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Meijboom, Rosanne W. Gardarsdottir, Helga Becker, Matthijs L. de Groot, Mark C. H. Movig, Kris L. L. Kuijvenhoven, Johan Egberts, Toine C. G. Leufkens, Hubert G. M. Giezen, Thijs J. Switching TNFα inhibitors: Patterns and determinants |
title | Switching TNFα inhibitors: Patterns and determinants |
title_full | Switching TNFα inhibitors: Patterns and determinants |
title_fullStr | Switching TNFα inhibitors: Patterns and determinants |
title_full_unstemmed | Switching TNFα inhibitors: Patterns and determinants |
title_short | Switching TNFα inhibitors: Patterns and determinants |
title_sort | switching tnfα inhibitors: patterns and determinants |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305431/ https://www.ncbi.nlm.nih.gov/pubmed/34302442 http://dx.doi.org/10.1002/prp2.843 |
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